The Anticancer Drugs

The Anticancer Drugs

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Description

This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. It is extensively referenced and provides a historical background for the development of each class of drugs. The authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine in writing this text.show more

Product details

  • Paperback | 360 pages
  • 175.3 x 249.4 x 16.3mm | 671.33g
  • Oxford University Press Inc
  • New York, United States
  • English
  • Revised
  • 2nd Revised edition
  • line figures and tables
  • 0195067398
  • 9780195067392

Table of contents

PART I: PRINCIPLES OF CANCER CHEMOTHERAPY; 1. The cancer problem; 2. Some milestones in the development of cancer chemotherapy; 3. Determinants of drug responsiveness; 4. Resistance to anticancer drugs; PART II: THE ANTICANCER DRUGS; 5. Antimetabolites; 6. Covalent DNA binding drugs; 7. Non-covalent DNA binding drugs; 8. Inhibitors of chromatin function; 9. Drugs affecting endocrine function; PART III: CLINICAL CANCER CHEMOTHERAPY; 10. Choice of drugs for cencer chemotherapy; PART IV: NEW DIRECTIONS IN CANCER CHEMOTHERAPY; 11. Anticancer drug development; 12. Biological treatments of cancer; 13. Potential targets for new anticancer drugsshow more