Part 1 Agents: the decade of the brain, M. Williams; pharmacological intervention in sleep and circadian processes, J.D. Miller; advances in central serotoninergics, A.G. Romero and A.B. McCall; traumatic and ischemia/reperfusion injury to the CNS, J.M. McCall and J.A. Panetta; trophic factors and their receptors in the CNS, S. Rosenberg; antipsychotics, L.D. Wise and T.G. Heffner. Part 2 Cardiovascular and pulmonary agents: angiotensin/renin modulators, W.J. Greenlee and P.K.S. Siegl; EDRF, an emerging target for drug design, J.F. Kerwin, Jr; endogenous vasoactive peptides, A.M. Doherty; recent advances in antiarrhythmic therapy - potassium channel antagonists, M.G. Cimini and J.K. Gibson; future antithrombotic therapy, J.A. Jakubowski, et al; pulmonary and anti-allergy agents, R.T. Jacobs, et al. Part 3 Chemotherapeutic agents: antibacterial agents, targets, and approaches, M.J. Suto, et al; genetic engineering of antibiotic producing organisms, L. Katz and C.R. Hutchinson; inhibitors of angiogenesis, M.A. Mitchell and J.W. Wilks; recent advances in antifungal agents, J.F. Barrett and D.H. Klaubert; progress in antimicrobial peptides, S.W. Blondelle and R.A. Houghten; protein tyrosine kinases and cancer, E.M. Dobrusin and D.W. Fry. Part 4 Immunology, endocrinology, and metabolic diseases: monoclonal antibodies in therapy, G.A. Heavner; techniques for determining epitopes for antibodies and T-cell receptors, D.C. Benjamin and S.S. Perdue; potential therapeutic modifiers of the complement cascade, W.K. Hagmann and R.D. Sindelar; cytokine modulation as medicinal chemistry target, K. Cooper and H. Masamune; recent advances in the discovery and development of potential antidiabetic agents, J.R. Colca and S.P. Tanis. Part 5 Topics in biology: the role of homeobox genes in vertebrate embryonic development, K. Mahon and M. Jamrich; emerging therapies for cystic fibrosis, A.E. Smith; the guanylyl cyclase family of receptor/enzymes, H.-J. Fulle and D.L. Garbers; HIV vaccine development - from empiricism to medicinal chemistry, M.J. Glass and W.C. Kogg; inositol triphosphate receptors, S.K. Joseph. Part 6 Topics in drug design and discovery: macromolecular X-ray crystalloglraphy and NMR as tools for structure-based drug design, J.W. Erickson and S.W Fesik. Part contents.