Annual Reports in Medicinal Chemistry: Volume 45

Annual Reports in Medicinal Chemistry: Volume 45

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Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
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Product details

  • Paperback | 648 pages
  • 152.4 x 226.06 x 33.02mm | 816.46g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 0123809029
  • 9780123809025

Table of contents

Section I: Central Nervous System Diseases - ROBICHAUD

Voltage-Gated Calcium Channel Antagonists for the Central Nervous System
James C. Barrow and Joseph L. Duffy

Recent Developments in Glycine Transporter-1 Inhibitors
Christopher L. Cioffi, Shuang Liu and Mark A.Wolf

Modulators of Transient Receptor Potential Ion Channels
Rajagopal Bakthavatchalam and S. David Kimball

Defining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-species Pharmacologic Exposure-Response Relationships
Christopher L. Shaffer

Section II: Cardiovascular and Metabolic Diseases - STAMFORD

High Affinity Niacin Receptor GPR109A Agonists
Hong C. Shen and Steven L. Colletti

Recent Advances in Acetyl CoA Carboxylase (ACC) Inhibitors
Matthew P. Bourbeau, John G. Allen, and Wei Gu

Enzymatic Targets in the Triglyceride Synthesis Pathway
Dmitry O. Koltun and Jeff Zablocki

Inhibitors of HIF Prolyl Hydroxylases
Michael H. Rabinowitz, Terrance D. Barrett, Mark D. Rosen, Hariharan Venkatesan

Section III: Inflammation / Pulmonary / GI - BARRISH/Weinstein

Opioid Receptor Antagonists for Gastrointestinal Dysfunction
R. William Hipkin and Roland E. Dolle

CFTR Modulators for the Treatment of Cystic Fibrosis
Sabine Hadida, Frederick Van Goor and Peter D. J. Grootenhuis

Targeting B-cells in inflammatory disease
Kevin S. Currie

Modulators of Toll-Like Receptor (TLR) Signaling
Mark Spyvee, Lynn Hawkins, and Sally Ishizaka

Section IV: Oncology - McAlpine

Janus Kinase 2 (JAK2) inhibitors for the treatment of myeloproliferative neoplasm (MPN)
Ashok V. Purandare, Matthew V. Lorenzi and Louis J. Lombardo

Development of poly(ADP-ribose)polymerase (PARP) inhibitors in oncology
Philip Jones

Epigenetic Targets and Cancer Drug Discovery
Patrick M. Woster, Ph.D

Section V: Infectious Diseases - Primeau

HIV-1 Integrase Strand Transfer Inhibitors
Brian A. Johns

Recent Advances in Drug Discovery for Neglected Tropical Diseases Caused by Infective Kinetoplastid Parasites
Robert T. Jacobs and Charles Ding

Recent Advances in the Inhibition of Bacterial Fatty Acid Biosynthesis
Vincent Gerusz

Section VI: Topics in Biology - LOWE

Back to the Plaque: Emerging Studies That Re-Focus Attention on the Neuritic Plaque in Alzheimer's Disease
Dr. Robert B. Nelson

Targeting Methyl Lysine
Stephen V. Frye, Tom Heightman and Jian Jin

Chemical Proteomic Technologies for Drug Target Identification
Kieran F. Geoghegan and Douglas S. Johnson

NIH Translational Programs for Assisting Pre-Clinical Drug Discovery and Development
Raj N. Misra

Section VII: Topics in Drug Design and Discovery - DESAI

Role of Physicochemical Properties and Lipophilic Ligand Efficiency (LipE or LLE) in addressing Drug Safety Risks
Martin P. Edwards and David A. Price

Reducing the Risk of Drug Attrition Associated with Physicochemical Properties
Paul D. Leeson and James R. Empfield

Compound Collection Enhancement and Paradigms for High Throughput Screening - an Update
Stevan W Djuric, Irini Akritopoulou-Zanze, Philip B Cox and Scott Galasinski

The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties
Kevin J. Hodgetts, Kerry J. Combs, Amy M. Elder and Geraldine C. Harriman

Patents in Drug Discovery: Case Studies, Examples, and Simple Steps Medicinal Chemists Can Take to Protect Hard-Won Intellectual Property
Charles J. Andres, Jr. and Richard L. Treanor

Section VIII: Trends and Perspectives

To Market, To Market - 2009

Shridhar Hegde and Michelle Schmidt
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