Preface. List of Contributors. New Pharmacokinetic Concepts; P.S.A. Glass. The Biophase Concept; D.R. Stanski. Handedness in Anesthetic Pharmacology; T.D. Egan. Anesthetics and Ventilatory Drive; P.L. Bailey. When does the Infant Mature Pharmacologically; D.M. Fisher. Brain Imaging for Elucidating Mechanisms of Anesthesia; P. Fiset. Is Pharmacokinetics Relevant? D.M. Fisher. Physiologic vs. Pharmacologic Sleep; P. Fiset. Awareness under Anesthesia: Current Understanding; P.S. Sebel. Depth of Anesthesia Monitoring Techniques: an Overview; D.R. Stanski. Bispectral Index Monitoring Technology: an Overview; C.E. Rosow. Bispectral Monitoring Technology: Clinical Applications; P.S. Sebel. Target Controlled Drug Delivery in Anesthesiology; S.E. Kern. The Principles of Total Intravenous Anesthesia (TIV A); P.S.A. Glass. Transmucosal and Other New Drug Delivery Technologies; Th.H. Stanley. A Concept for Assessing Anesthetic Interactions; I. Kissin. Drug Interactions: Opioids and Sedative Hypnotics; C. Rosow. Interactions: General Principles; I. Kissin. Drug Interactions: Opioids and Inhaled Anesthetics; P.S.A. Glass. An Update on the Clinical Use of Propofol; P.F. White. Kinetic Considerations in the Selection of an Inhaled Anesthetic; E.I. Eger II. Controversies Regarding Sevoflurane & Desflurane Toxicity; E.I. Eger II. The Role of Alpha2 Agonists in Anesthesiology; M. Maze. Current Concepts in Anti-Emetic Therapy, P.F. White. New Insights Into Muscle Relaxants; D.M. Fisher. Remifentanil: Clinical Applications; T.D. Egan. Drug Addiction Among Anesthesiologists; M. Maze. Antagonism of Anesthetic Effects; P. Fiset. Economics of Anesthesia Education; P.S. Sebel. The Role of Ketamine in Anesthetic Practice; P.F. White.