American Trypanosomiasis

American Trypanosomiasis : Chagas Disease One Hundred Years of Research

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Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: * The host: human and mammalian reservoirs* The insect vectors: domestic and sylvatic vectors* The causative parasite: Trypanosoma cruzi
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Product details

  • Hardback | 870 pages
  • 154 x 232 x 62mm | 1,428.81g
  • United States
  • English
  • New.
  • 0123848768
  • 9780123848765
  • 2,146,060

Table of contents

PART I - GENERAL ASPECTS 1. History of the discovery of the American Trypanosomiasis (Chagas disease) Tania Araujo-Jorge, Jenny Telleria, and Jaime Rios Dalenz 2. Chagas disease in pre-Colombian civilizations Felipe Guhl and Arthur Aufderheide 3. Social and Medical aspects: morbidity and mortality in the general population Joao Carlos Pinto Dias and Christopher John Schofield 4. Current trends and future prospects for control of Chagas disease Alvaro Moncayo and Antonio Carlos Silveira 5. Geographical distribution of Chagas disease James S. Patterson and Felipe Guhl PART II - INSECT VECTORS 6. Classification and Phylogeny of the Triatominae Maria Dolores Bargues, Chris Schofield and Jean-Pierre Dujardin 7. Biology of Triatominae Francois Noireau and Jean-Pierre Dujardin 8. Population Genetics of Triatomines Fernando Monteiro, Paula Marcet and Patricia Dorn 9. Geographical distribution of Triatominae vectors in America David Gorla and Francois Noireau 10. Control strategies against Triatominae D.E.Gorla, C.Ponce, J-P.Dujardin and C.J.Schofield PART III - NON-HUMAN MAMMALIAN HOSTS 11. Domestic and wild mammalian reservoirs Ana Maria Jansen and Andre Luiz Rodrigues Roque 12. Veterinary aspects and experimental studies Marc Desquesnes and Marta de Lana PART IV - THE CAUSATIVE AGENT: TRYPANOSOMA CRUZI 13. Classification and phylogeny of Trypanosoma cruzi Patrick B. Hamilton and Jamie R. Stevens 14. Biology of Trypanosoma cruzi and biological diversity Marta de Lana and Evandro Marques de Menezes Machado 15. Biochemistry of Trypanosoma cruzi Roberto Docampo and Silvia N. J. Moreno 16. Ultrastructure of Trypanosoma cruzi and its Interaction with Host Cells Wanderley de Souza, Tecia Ulisses de Carvalho, Emile Santos Barrias 17. Genetics of Trypanosoma cruzi Sub-chapter: Nuclear genome Daniella C. Bartholomeu, Gregory A. Buck, Santuza M. R. Teixeira, Najib M. A. El- Sayed Sub-chapter: Kinetoplast genome Jenny Telleria, Michal Svoboda 18. Experimental and Natural recombination in Trypanosoma cruzi Michael D. Lewis, Martin S. Llewellyn, Matthew Yeo, Michael A. Miles 19. Reticulate Evolution in Trypanosoma cruzi: medical and epidemiological implications Michel Tibayrenc, Christian Barnabe and Jenny Telleria 20. Implications of Trypanosoma cruzi intraspecific diversity in the pathogenesis of Chagas Disease Andrea Macedo PART V - MODES OF TRANSMISSION 21. Vector transmission Simone Frederique Breniere, Christine Aznar and Mireille Hontebeyrie 22. Maternal-fetal transmission of Trypanosoma cruzi Yves Carlier and Carine Truyens 23. Other forms of transmission Mireille Hontebeyrie, Simone Frederique Breniere and Christine Aznar PART VI - IMMUNOLOGY: HOST-PARASITE INTERACTION 24. Protective host response to parasite and its limitations Carine Truyens and Yves Carlier 25. Pathological consequences of host response to parasite Mireille Hontebeyrie , Carine Truyens and Simone Frederique Breniere 26. Human genetic susceptibility to Chagas disease Michel Tibayrenc PART VII - PATHOLOGY, DIAGNOSIS AND TREATMENT 27. Clinical phases and forms of Chagas' disease Joffre Marcondes de Rezende, Anis Rassi, Alejandro O. Luquetti and Anis Rassi Junior 28. Diagnosis of Trypanosoma cruzi infection Alejandro O. Luquetti and Gabriel A. Schmunis 29. AIDS and Chagas' disease Marcelo Corti, Maria F. Villafane 30. Treatment of Chagas disease Werner Apt 31. Vaccine development for Chagas disease Angel Marcelo Padilla, Cecilia Perez Brandan and Miguel Angel Basombrio
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About Michael Tibayrenc

Jenny Telleria, the initiator of the present book, got her PhD degree in the area of population genetics and parasitology at the University of Montpellier, France. She started her work in the area of parasitology in 1990 as university teacher assistant. Since then she has focused her research on the three components of Chagas disease, namely: the host, the vector and mainly the parasite (Trypanosoma cruzi). She has worked in several countries in Latin America and Europe, (Bolivia, Brazil, Venezuela, Belgium and France). She has presently a permanent position of Research Engineer at the French "Institut de recherche pour le developpement" (IRD) and she has been Dr Michel Tibayrenc's collaborator for more than 17 years. At present, she works at the Center of Research in health of Latin America "CISeAL", Quito-Nayon, Ecuador. Recent research deals with experimental evolution of T. cruzi, more specifically the parasite's gene expression surveyed by proteomics analysis. Michel Tibayrenc, MD, PhD, has worked on the evolution of infectious diseases for more than 35 years. He is a director of research emeritus at the French Institut de Recherche pour le Developpement (IRD), the founder and editor-in-chief of Infection, Genetics and Evolution (Elsevier), with a 2014 impact factor of 3.015, and the founder and principal organizer of the international congresses MEEGID (molecular epidemiology and evolutionary genetics of infectious diseases). He is the author of more than 200 international papers. He has worked for one year in Algeria (as a general practitioner), one year in French Guiana, seven years in Bolivia, five years in the United States, and three years in Thailand. He has been the head of the unit of research "genetics and evolution of infectious diseases" at the IRD research center in Montpellier, France, for 20 years. With his collaborator Jenny Telleria, he is the founder and scientific adviser of the Bolivian Society of Human Genetics (2012). He has won the prize of the Belgian Society of tropical medicine (1985), the medal of the Instituto Oswaldo Cruz, Rio de Janeiro (2000), for his work on Chagas disease, and he is a fellow of the American Association for the Advancement of Science (1993).
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