Advances in Protein Chemistry and Structural Biology: Volume 80
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Advances in Protein Chemistry and Structural Biology: Volume 80

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Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.
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Product details

  • Hardback | 296 pages
  • 152.4 x 231.14 x 10.16mm | 635.03g
  • Academic Press Inc
  • San Diego, United States
  • English
  • New
  • 012381264X
  • 9780123812643

About Rossen Donev

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.
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Table of contents

Proteomics technologies for the global identification and quantification of proteins
Ian A. Brewis and P. Brennan

Targeted metabolomics and mass spectrometry
E. Dudley, M. Yousef, Y. Wang, W.J. Griffiths

Mechanisms of Protein Circular Dichroism: Insights from Computational Modelling
Tatyana Karabencheva and Christo Christov

Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling
Jonathan G. L. Mullins, Seo-Kyung Chung and Mark I. Rees

Positive and Negative Modulation of Nicotinic Receptors
Hugo R. Arias

Sonochemically Born Proteinaceous Micro- and Nanocapsules

Elena D. Vassileva and Neli S. Koseva
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