Advances in Pharmacology: v.34

Advances in Pharmacology: v.34

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Part of a series providing reviews on pharmacological topics, this volume contains chapters addressing diverse but closely interrelated areas in chemistry, biochemistry, molecular biology, and pharmacology of nitric oxide in mammalian cells. Key features include: coverage of the chemical properties of nitric oxide and how they form the basis for the multifaceted biological actions of nitric oxide; current and detailed documentation of the properties and regulation of nitric oxide synthases; and a review of inhalational nitric oxide therapy for treatment of respiratory dysfunction.
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Product details

  • Hardback | 480 pages
  • 151 x 229mm | 894g
  • Academic Press Inc
  • San Diego, United States
  • illustrations, index
  • 0120329352
  • 9780120329359

Table of contents

Chemistry of nitric oxide - biologically relevant aspects, J.M. Fukuto; reactions between nitric oxide, superoxide and peroxynitrite - footprints of peroxynitrite "in vivo", J.P. Crow and J.S. Beckman; oxygen radical-nitric oxide reactions in vascular diseases, B.A. Freeman et al; nitric oxide synthases - gene structure and regulation, Y. Wang and P.A. Marsden; transcription of the human neuronal nitric oxide synthase gene in the central nervous system is mediated by multiple promoters, A.P. Young et al; regulation of the expression of the inducible isoform of nitric oxide synthase, C. Szabo and C. Thiemermann; regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation, J.M. Wong and T.R. Billiar; expression and expressional control of nitric oxide synthases in various cell types, U. Forstermann et al; control and consequences of endothelial nitric oxide formation, I. Fleming and R. Busse; control of electron transfer in neuronal nitric oxide synthase by calmodulin, substrate, substrate analogs and nitric oxide, D.J. Stuehr et al; negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds, J.M. Griscavage et al; regulation of nitric oxide synthase - role of oxygen-radicals and cations in nitric oxide formation, C.K. Mittal and C.S. Mehta; why tetrahydrobiopterin?, B. Mayer and E.R. Werner; nitric oxide and cyclic GMP signalling, L.J. McDonald and F. Murad; nitric oxide and intracellular heme-1, Y.-M. Kim et al; high level expression of biologically active soluble guanylyl cyclase using the baculovirus system is strongly heme-dependent, W.A. Buechler et al; cGMP signalling through cAMP- and cGMP-dependent protein kinases, T.M. Lincoln et al; physiological and toxicological actions of nitric oxide in the central nervous system, V.L. Dawson and T.M. Dawson; S-nitrosothiols - chemistry, biochemistry and biological actions, G.R. Upchurch et al; glyceraldehyde-3-phosphate dehydrogenase - a target for nitric oxide signalling, B. Brune and E.G. Lapetina; nitric oxide donors - biochemical pharmacology and therapeutics, J.A. Bauer et al; nitric oxide donors - a continuing opportunity in drug design, S.R. Hanson et al; nitric oxide and peripheral adrenergic neuromodulation, R. Levi et al; a study on tumor necrosis factor, tumor necrosis factor receptors and nitric oxide in human fetal glial cultures, B.A. St.Pierre et al; inhaled nitric oxide, clinical rationale and applications, C.G. Frostell and W.M. Zapol; inhaled nitric oxide therapy of pulmonary hypertension and respiratory failure in premature and term neonates, S.H. Abman and J.P. Kinsella; clinical applications of inhaled nitric oxide in children with pulmonary hypertension, D.L. Wessel and I. Adatia.
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