Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry

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This volume surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early reviews in this field merely touched on certain aspects of the related chemistry. This is the first in-depth systematic treatment of the subject. The material is of particular importance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates in the synthesis of antimalarial agents. The literature reviewed has led to the discovery of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, as well as the new quinolones that are active against AIDS-related Legionella spp.
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Product details

  • Hardback | 452 pages
  • Academic Press Inc
  • San Diego, United States
  • English
  • references, index
  • 0120207540
  • 9780120207541

Table of contents

Work in the 19th century; structure of aminomethylenemalonates. Part 1 Syntheses: sytheses of kialkly 1-aminoalkylidenemalonates; syntheses of alkylidene 1-aminoalkylidenemalonates; syntheses of 2-azacycloalkylidenemalonates. Part 2 Cyclization of 1-aminoalkylidenemalonates: cyclization of dialkyl aminoalkylidenemalonates; cyclization of alkylidene aminomethylenemalonates; cyclization of azacycloalkylidenemalonates; further ring closure. Part 3 Other reaction of aminomethylenemalonates: reactions of dialkyl 1-aminoalkylidenemalonates;reactions of alkylidene aminomethylenemalonates; reaction of 2-azacycloalkylidenemalonates; miscellaneous methods; recent research appendix.
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