Advances in Cancer Research: v. 66

Advances in Cancer Research: v. 66

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"Advances in Cancer Research" is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Volume 66 contains encompassing overviews of p53 and its role in both breast cancer and in the cell cycle. Approximately 50% of all human tumors involve mutations of the p53 gene, suggesting that proper understanding of its properties and mechanisms could offer real hope for finding successful clinical therapy. Other themes presented in volume 66 include cyclins and cyclin-dependent kinases in the cell cycle; the molecular genetics of 11q23 chromosome translocations; the possible link between the aberrant expression of Scatter Factor and c-Met with AIDS associated Kaposi's sarcoma; the use of radiation leukemia virus to induce leukemogenesis; and the adenovirus system as a model for the insertion of foreign DNA into mammaliam genomes. Also of note in the "Foundations of Cancer Research" section are articles by two prominent cancer researchers recollecting the ideas and paths taken in their lifelong work. Paradigms proposed in these reviews mark thoughtful progress toward preventive therapy in oncogenesis and gene therapy of cancer.
They also cast light on the fact that the ideas presented in these chapters are only the tip of the iceberg in this complex and ever-evolving field, and suggest many more to come in future volumes.
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Product details

  • Hardback | 376 pages
  • 159 x 235 x 12.7mm | 663g
  • Academic Press Inc
  • San Diego, United States
  • English
  • index
  • 0120066661
  • 9780120066667

Table of contents

Part 1 Foundations in cancer research articles: the adventures of a biologist - prenatal diagnosis, hematopoiesis, leukemia, carcinogenesis, and tumor suppression, L. Sachs; from Aristotle, through Spemann, to tumor immunology (a personal experience), M. Feldman. Part 2 Regular articles: tumor suppressor p53 mutations and breast cancer - a critical analysis, M.A. Ozbun and J.S. Butel; p53 - a cell cycle regulator activated by DNA damage, G. Selivanova and K.G. Wiman; cyclins and cyclin-dependent kinases - theme and variations, J. Pines; molecular genetics of 11q23 chromosome translocations, E. Canaani et al; role of scatter factor and the "c-Met" proto-oncogene in the pathogenesis of AIDS associated Kaposi's sarcoma, P.J. Polverini and B.J. Nickoloff; REL/NF-kB/IkB story, S. Miyamoto and I.M. Verma; radiation leukemia virus (RADLV) induced leukemogenesis - a paradigm of preleukemia and its control by preventive therapy, E. Yefenof and M. Kotler; the insertion of foreign DNA into mammalian genomes and its consequences - a concept in oncogenesis, W. Doerfler.
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Review quote

Praise for the Serial "This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." -AMERICAN SCIENTIST "Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced." JOURNAL OF MEDICINAL CHEMISTRY "Oncologists as well as other researchers and clinicians employing interferon will find this survey of interest." -BIOLOGICAL ABSTRACTS
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About George Klein

Edited by George F. Vande Woude, and George Klein
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