Adult Stem Cells

Adult Stem Cells

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Studies on stem cells have been attracting intense scientific and p- lic attention, not only because of controversies surrounding the use of embryonic stem cells but also because of very provocative data that have been emerging on adult stem cells. Much of the public attention and debate has been focused on the possibility that adult stem cells may be used as a substitute for human embryonic stem cells or as a justification for stopping work on them. This has somewhat dim- ished attention on very heated scientific debates that take us to the very heart of how the concept of stem cells is perceived. To this author, the latter debates have not been unlike certain philosophical debates of the last century. Since the seminal studies of Till and McCulloch in the 1960s, the popular paradigm on adult stem cells has been that lineage-restricted stem cells are derived from pluripotent stem cells very early during development. To many, and consistent with much data, the restriction to particular lineages was considered absolute. In other words, there was a sense of determinism in the stem quality of particular stem cells: once they were allocated, they were programmed to specific roles in a given tissue. Furthermore, some adult tissues were considered devoid of detectable stem cell presence or more

Product details

  • Hardback | 346 pages
  • 157.5 x 233.7 x 20.3mm | 748.44g
  • Humana Press Inc.
  • Totowa, NJ, United States
  • English
  • 2004 ed.
  • 9 Illustrations, color; 49 Illustrations, black and white; XIII, 346 p. 58 illus., 9 illus. in color.
  • 1588291529
  • 9781588291523

Back cover copy

Recent years have seen ever increasing interest in the discovery of adult stem cells and the elucidation of their properties. During this time, much basic research has been carried out, with the results now clearly holding high promise for regenerative medicine. In Adult Stem Cells, a worldwide cohort of distinguished investigators critically reviews these many studies to produce a state-of-the-art understanding of adult stem cell types and their regulation. These authors examine the derivation, characterization, and utility of adult stem cells found in skeletal muscle, dental pulp, prostate, kidney, the eye, inner ear, and other tissues. They pay special attention to adult stem cell plasticity and their utility in normal tissue homeostasis, as well as their applications in regenerative medicine. Detailed discussions allow ready comparisons among the models and approaches used for each tissue and cell type covered. Comprehensive and state-of-the-art, Adult Stem Cells not only illuminates for both experienced and novice investigators the nature, culture, and potentiality of adult stem cells, but also enhances productive exploration of their rapidly growing applications in regenerative more

Review quote

"This beautiful, hardcover book features glossy pages, exquisite color plates, and expert technical writing. Chapters include informative line drawings, photomicrographs, and an extensive bibliography. The diversity of topics will certainly capture the attention of a wide audience of readers. The book is compact and very readable. I enjoyed this book, and was surprised by the attention focused on different types of adult stem cells. The topic is timely. This book hopefully will be a stimulus for new researchers to enter the field. " - Doody's Health Sciences Book Review Journal "This book contains an extensive review of liver stem cell research, including experimentation with extrahepatic tissue and sites. I would highly recommend this book for medical libraries as well as academic libraries at institutions with graduate programs in genetics, biochemistry, cell biology, neuroscience or molecular biology." -E-STREAMSshow more

Table of contents

Adult Stem Cell Plasticity William B. Slayton and Gerald J. Spangrude Spermatogonial Stem Cells Dirk G. de Rooij Stem Cells in Skeletal Muscle Anna Polesskaya and Michael Rudnicki Gene Therapy Using Muscle-Derived Stem Cells Christopher Chermansky, Johnny Huard, and Michael B. Chancellor Human Dental Pulp Stem Cells: Characterization and Developmental Potential Stan Gronthos, Natasha Cherman, Pamela Gehron Robey, and Songtao Shi Epithelial Stem/Progenitor Cells in Thymus Organogenesis Hans-Reimer Rodewald Adult Liver Stem Cells William B. Coleman, Joe W. Grisham, and Nadia N. Malouf Endothelial Progenitor Cells Takayuki Asahara and Jeffrey M. Isner Prostate Epithelial Stem Cells Anne T. Collins and David E. Neal Mammary Epithelial Stem Cells Elizabeth Anderson and Robert B. Clarke From Marrow to Brain Josef Priller Adult Retinal Stem Cells Monica L. Vetter and Edward M. Levine Multipotentiality of Iris Pigment Epithelial Cells in Vertebrate Eye Mitsuko Kosaka, Guangwei Sun, Masatoshi Haruta, and Masayo Takahashi Stem Cell Biology of the Inner Ear and Potential Therapeutic Applications Thomas R. Van De Water, Ken Kojima, Ichiro Tateya, Juichi Ito, Brigitte Malgrange, Philippe P. Lefebvre, Hinrich Staecker, and Mark F. Mehler Engineering the In Vitro Cellular Microenvironment for the Control and Manipulation of Adult Stem Cell Responses Ali Khademhosseini and Peter W. Zandstra Stem Cells As Common Ancestors: Somatic Cell Phylogenies From Somatic Sequence Alterations Darryl Shibata Indexshow more