Adenoviral Vectors for Gene Therapy

Adenoviral Vectors for Gene Therapy

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Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research.

This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors.
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Product details

  • Hardback | 868 pages
  • 152 x 229 x 38.1mm | 1,200g
  • Academic Press Inc
  • San Diego, United States
  • English
  • 2nd edition
  • black & white illustrations
  • 012800276X
  • 9780128002766

Table of contents

Adenovirus Structure Biology of Adenovirus Cell Entry Adenovirus Replication Adenoviral Vector Construction I: Mammalian Systems, Adenoviral Vector Construction II: Bacterial Systems Propagation of Adenoviral Vectors: Use of PER.C6 Cells Purification of Adenovirus Targeted Adenoviral Vectors I: Transductional Targeting Targeted Adenoviral Vectors II: Transcriptional Targeting Development of Attenuated Replication Competent Adenoviruses (ARCAs) for the treatment of Prostate Cancer Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer Innate Immune Responses to in Vivo Adenovirus Infection Humoral Immune Response Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications Xenogenic Adenoviral Vectors Hybrid Adenoviral Vectors Utiliity of Adenoviral Vectors in Animal Models of Human Disease I: Cancer Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations Imaging Adenovirus-Medicated Gene Transfer
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About David T. Curiel

David T. Curiel, M.D., Ph.D. is the Director of the Cancer Biology Division of the Department of Radiation Oncology at Washington University School of Medicine. Dr. Curiel graduated medical school at Emory University in 1982, where he also completed his internship and residency in Internal Medicine. Dr. Curiel's scientific training includes tenureship at the National Institutes of Health in Bethesda, Maryland at the Pulmonary Branch of the Heart and Lung, and Blood Institute (NHLBI) from 1985-1989, and a fellowship in Biotechnology at the National Cancer Institute, Navy Medical Oncology Branch from 1989-1990. He received his Ph.D. from University of Groningen in The Netherlands in 2002. Dr. Curiel has been at Washington University School of Medicine since 2011. In addition to his role as Director of the Cancer Biology Division, he is Director of the Biologic Therapeutics Center.
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