Adaptive Evolution of Genes and Genomes

Adaptive Evolution of Genes and Genomes

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Description

This valuable book thoroughly examines adaptive evolution at the DNA level while taking a comprehensive look at the research being done in the area. It presents useful cases where signals of adaptive evolution are detected through neutral molecular evolution, providing a powerful strategy for testing the Darwinian hypothesis of natural selection. By bridging the gap between research on molecular and phenotype evolution and contributing to the unification of the biological sciences, this book will especially appeal to researchers and graduate students in the field of evolutionary biology. Also, with its focus on particular protein molecules and on specific domains of these proteins, it will benefit a wider audience of both evolutionary and functional biologists.show more

Product details

  • Hardback | 282 pages
  • 162.56 x 236.22 x 25.4mm | 544.31g
  • Oxford University Press Inc
  • New York, United States
  • English
  • 95 line illustrations
  • 0195116267
  • 9780195116267

Table of contents

What is adaptive evolution?; methods of sequence analysis; the neutral theory; balancing selection: the major histocompatibility complex; balancing selection - other examples; directional selection; evolution of new protein function; adaptive characteristics of genomes.show more

Review quote

"Only during the last decade did molecular evolution finally become capable of studying Darwinian selection. Although the evolution of most nucleotides, at any particular moment, is governed by mutation, drift, and/or purifying selection, still there is plenty of room left for adaptive evolution. Many fascinating discoveries have already been made, and Hughes provides the first comprehensive review. ... The first two chapters provide a non-technical review of sequence analysis and a good exposition of what is certainly true and important in neutralism . . . After this, the exposition moves from balancing selection ... to directional selection acting on individual molecules, to evolution of new molecules and functions and finally to adaptation at the level of the whole genome. One can hardly propose a better structure. A lot of very interesting data are presented in clear and readable way. ... I strongly recommend [this book] to anybody interested in molecular evolution."--Trends in Genetics"This book is clearly written. The examples given illustrate various aspects of Darwinian positive selection pressure exerted on specific genes. These examples are discussed in sufficient detail to be easily understood by readers not too familiar with the subject. . . .the author has achieved the aim of providing a general biological audience with basic knowledge and up to date facts and opinions about a central aspect of natural selection." --Genetcis, Selection, Evulutionshow more

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