This is the first comprehensive account of heredity acetylation polymorphisms in humans and animals. Its premise is that individual differences in the human response to drugs and other chemicals are profoundly influenced by genetics and are much more common than is thought. Acetylation is the mechanism by which the body disposes of many chemicals encountered in everyday life, including numerous drugs and certain chemical carcinogens found in the workplace. It occupies a unique position in pharmacogenetics, as there is no better example of how a multiplicity of genetically determined differences in drug response can arise from a single metabolic theme, or of how the understanding of a pharmacogenetic trait can be used to prevent human illness of environmental origin. This monograph assesses the role of drug acetylation as a genetic factor capable of altering individual susceptibility to therapeutic drug effects, toxicity, and spontaneous illness resulting from amines and hydrazines. It provides a unified account of the genetic and biochemical features of acetylation polymorphisms and of their therapeutic, pharmacolgical, and toxicological significance.
Geneticists, pharmacologists, toxicologists, physicians specializing in industrial medicine or hygiene, and clinical chemists.show more