Accurate Results in the Clinical Laboratory

Accurate Results in the Clinical Laboratory : A Guide to Error Detection and Correction

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This practical, easy-to-use guide, named to Doody's Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care. Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.
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Product details

  • Hardback | 382 pages
  • 215.9 x 279.4 x 25.4mm | 1,202.01g
  • United States
  • English
  • black & white illustrations, black & white tables, figures
  • 0124157831
  • 9780124157835
  • 1,552,528

Table of contents

Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory Chapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test Results Chapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory tests Chapter 4. Sample processing and specimen misidentification issues Chapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory tests Chapter 6. Immunoassay design and mechanism of interferences Chapter 7. Effect of herbal remedies on clinical laboratory tests Chapter 8. Challenges in routine clinical chemistry: analysis of small molecules Chapter 9. Challenges in routine clinical chemistry: proteins and enzymes Chapter 10. Sources of inaccuracy in biochemical genetics analysis Chapter 11. Challenges in endocrinology testing Chapter 12. Pitfalls in tumor marker testing Chapter 13. Issues of interferences in therapeutic drug monitoring Chapter 14. Limitations of drugs of abuse testing Chapter 15. Challenges in confirmation testing for drugs of abuse Chapter 16. Alcohol determination using automated analyzers: limitations and pitfalls Chapter 17. Pre-analytical issues and interferences in transfusion medicine tests Chapter 18. Critical issues in immunology and serology testing Chapter 19. Sources of errors in hematology and coagulation testing Chapter 20. Challenges in Clinical Microbiology Testing Chapter 21. Sources of errors in molecular testing Chapter 22. Problems in Pharmacogenomics Testing
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Review quote

"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation."--Reference and Research Book News, August 2013 "This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease.", August 9, 2013
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About Jorge L Sepulveda

Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis. Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.
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