Accessible Surface Area

Accessible Surface Area

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Description

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. The accessible surface area or solvent-accessible surface area is the surface area of a biomolecule that is accessible to a solvent. Measurement of ASA is usually described in units of square ngstroms. ASA was first described by Lee & Richards in 1971 and is sometimes called the Lee-Richards molecular surface. ASA is typically calculated using the 'rolling ball' algorithm developed by Shrake & Rupley in 1973. This algorithm uses a sphere of a particular radius to 'probe' the surface of the molecule. The Shrake-Rupley algorithm is a numerical method that draws a mesh of points equidistant from each atom of the molecule and uses the number of these points that are solvent accessible to determine the surface area. The points are drawn at a water molecule's estimated radius beyond the van der Waals radius, which is effectively similar to 'rolling a ball' along the surface. All points are checked against the surface of neighboring atoms to determine whether they are buried or accessible.show more

Product details

  • Paperback | 60 pages
  • 152 x 229 x 4mm | 100g
  • Vent
  • United States
  • English
  • black & white illustrations
  • 6136286114
  • 9786136286112