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    Von Willebrand Disease: Basic and Clinical Aspects (Hardback) Edited by Augusto B. Federici, Edited by Christine A. Lee, Edited by Erik E. Berntorp, Edited by David Lillicrap, Edited by Robert R. Montgomery

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    DescriptionVon Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.


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  • Full bibliographic data for Von Willebrand Disease

    Title
    Von Willebrand Disease
    Subtitle
    Basic and Clinical Aspects
    Authors and contributors
    Edited by Augusto B. Federici, Edited by Christine A. Lee, Edited by Erik E. Berntorp, Edited by David Lillicrap, Edited by Robert R. Montgomery
    Physical properties
    Format: Hardback
    Number of pages: 268
    Width: 188 mm
    Height: 248 mm
    Thickness: 20 mm
    Weight: 862 g
    Language
    English
    ISBN
    ISBN 13: 9781405195126
    ISBN 10: 1405195126
    Classifications

    BIC E4L: HEA
    B&T Book Type: NF
    Nielsen BookScan Product Class 3: S6.2
    Ingram Subject Code: PI
    Libri: I-PI
    B&T Modifier: Region of Publication: 03
    B&T General Subject: 510
    B&T Merchandise Category: MAJ
    B&T Modifier: Academic Level: 03
    B&T Modifier: Text Format: 06
    Warengruppen-Systematik des deutschen Buchhandels: 16940
    BIC subject category V2: MJF
    BISAC V2.8: MED000000, MED038000
    LC subject heading:
    DC22: 616.157, 616.1/57
    LC classification: RC647.V65 V66 2011
    LC subject heading: , ,
    Thema V1.0: MJF
    Edition
    1
    Publisher
    John Wiley and Sons Ltd
    Imprint name
    Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
    Publication date
    26 April 2011
    Publication City/Country
    Chicester
    Author Information
    Augusto B. Federici, University of Milan, Milan, Italy Christine A. Lee, Oxford Haemophilia & Thrombosis Centre, Oxford, UK Erik E. Berntorp, Lund University, Malmo, Sweden David Lillicrap, Queen's University, Kingston, ON, Canada Robert R. Montgomery, Medical College of Wisconsin; Milwaukee, WI, USA
    Review quote
    "This book certainly helped to enhance my knowledge about von Willebrand disease and even prompted me to present a review of the disease to my colleagues. It is excellently written, appeals to a broad category of readers, and exceeds its stated objectives. I would definitely recommend the book to colleagues." (Doody's, 23 September 2011)
    Back cover copy
    Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease.This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding.Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy.Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.
    Table of contents
    Contributors. Foreword. Preface. 1 Historical perspective on von Willebrand disease ( Erik Berntorp and Margareta Blomback ). 2 Biosynthesis and organization of von Willebrand factor ( Sandra L. Haberichter ). 3 von Willebrand factor structure and function ( Robert R. Montgomery and Sandra L. Haberichter ). 4 Modulation of von Willebrand factor by ADAMTS13 ( Jennifer Barr and David Motto ). 5 Animal models in von Willebrand disease ( Cecile V. Denis, Olivier D. Christophe and Peter J. Lenting 0. 6 Classifi cation of von Willebrand disease ( Javier Batlle, Almudena Perez-Rodriguez and Maria Fernanda Lopez-Fernandez ). 7 The epidemiology of von Willebrand disease ( Giancarlo Castaman and Francesco Rodeghiero ). 8 Clinical aspects of von Willebrand disease: bleeding history ( Paula D. James and Alberto Tosetto ). 9 Laboratory diagnosis of von Willebrand disease: the phenotype ( Ulrich Budde and Emmanuel J. Favaloro ). 10 Molecular diagnosis of von Willebrand disease: the genotype ( Anne C. Goodeve and Reinhard Schneppenheim ). 11 Clinical, laboratory, and molecular markers of type 1 von Willebrand disease ( David Lillicrap, Francesco Rodeghiero, and Ian Peake ). 12 Clinical, laboratory, and molecular markers of type 2 von Willebrand disease ( Dominique Meyer, Edith Fressinaud, and Claudine Mazurier ). 13 Clinical, laboratory, and molecular markers of type 3 von Willebrand disease ( Luciano Baronciani, Augusto B. Federici, and Jeroen C.J. Eikenboom ). 14 Pediatric aspects of von Willebrand disease ( Jorge Di Paola and Thomas Abshire ). 15 Women with von Willebrand disease ( Christine A. Lee, Rezan A. Kadir, and Peter A. Kouides ). 16 On the use of desmopressin in von Willebrand disease ( Stefan Lethagen, Augusto B. Federici, and Giancarlo Castaman ). 17 The use of plasma-derived concentrates ( Pier Mannuccio Mannucci and Massimo Franchini ). 18 Prophylaxis in von Willebrand disease ( Erik Berntorp ). 19 Pathophysiology, epidemiology, diagnosis, and treatment of acquired von Willebrand syndrome ( Ulrich Budde, Augusto B. Federici and Jacob H. Rand ). 20 Gene therapy for von Willebrand disease ( Marinee K.L. Chuah, Inge Petrus, and Thierry VandenDriessche ). Index.