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Von Willebrand Disease: Basic and Clinical Aspects

Von Willebrand Disease: Basic and Clinical Aspects

Hardback

Edited by Augusto B. Federici, Edited by Christine A. Lee, Edited by Erik E. Berntorp, Edited by David Lillicrap, Edited by Robert R. Montgomery

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  • Publisher: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
  • Format: Hardback | 268 pages
  • Dimensions: 188mm x 248mm x 20mm | 862g
  • Publication date: 26 April 2011
  • Publication City/Country: Chicester
  • ISBN 10: 1405195126
  • ISBN 13: 9781405195126
  • Edition: 1
  • Sales rank: 1,041,459

Product description

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

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Author information

Augusto B. Federici, University of Milan, Milan, Italy Christine A. Lee, Oxford Haemophilia & Thrombosis Centre, Oxford, UK Erik E. Berntorp, Lund University, Malmo, Sweden David Lillicrap, Queen's University, Kingston, ON, Canada Robert R. Montgomery, Medical College of Wisconsin; Milwaukee, WI, USA

Review quote

"This book certainly helped to enhance my knowledge about von Willebrand disease and even prompted me to present a review of the disease to my colleagues. It is excellently written, appeals to a broad category of readers, and exceeds its stated objectives. I would definitely recommend the book to colleagues." (Doody's, 23 September 2011)

Back cover copy

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease.This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding.Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy.Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

Table of contents

Contributors. Foreword. Preface. 1 Historical perspective on von Willebrand disease ( Erik Berntorp and Margareta Blomback ). 2 Biosynthesis and organization of von Willebrand factor ( Sandra L. Haberichter ). 3 von Willebrand factor structure and function ( Robert R. Montgomery and Sandra L. Haberichter ). 4 Modulation of von Willebrand factor by ADAMTS13 ( Jennifer Barr and David Motto ). 5 Animal models in von Willebrand disease ( Cecile V. Denis, Olivier D. Christophe and Peter J. Lenting 0. 6 Classifi cation of von Willebrand disease ( Javier Batlle, Almudena Perez-Rodriguez and Maria Fernanda Lopez-Fernandez ). 7 The epidemiology of von Willebrand disease ( Giancarlo Castaman and Francesco Rodeghiero ). 8 Clinical aspects of von Willebrand disease: bleeding history ( Paula D. James and Alberto Tosetto ). 9 Laboratory diagnosis of von Willebrand disease: the phenotype ( Ulrich Budde and Emmanuel J. Favaloro ). 10 Molecular diagnosis of von Willebrand disease: the genotype ( Anne C. Goodeve and Reinhard Schneppenheim ). 11 Clinical, laboratory, and molecular markers of type 1 von Willebrand disease ( David Lillicrap, Francesco Rodeghiero, and Ian Peake ). 12 Clinical, laboratory, and molecular markers of type 2 von Willebrand disease ( Dominique Meyer, Edith Fressinaud, and Claudine Mazurier ). 13 Clinical, laboratory, and molecular markers of type 3 von Willebrand disease ( Luciano Baronciani, Augusto B. Federici, and Jeroen C.J. Eikenboom ). 14 Pediatric aspects of von Willebrand disease ( Jorge Di Paola and Thomas Abshire ). 15 Women with von Willebrand disease ( Christine A. Lee, Rezan A. Kadir, and Peter A. Kouides ). 16 On the use of desmopressin in von Willebrand disease ( Stefan Lethagen, Augusto B. Federici, and Giancarlo Castaman ). 17 The use of plasma-derived concentrates ( Pier Mannuccio Mannucci and Massimo Franchini ). 18 Prophylaxis in von Willebrand disease ( Erik Berntorp ). 19 Pathophysiology, epidemiology, diagnosis, and treatment of acquired von Willebrand syndrome ( Ulrich Budde, Augusto B. Federici and Jacob H. Rand ). 20 Gene therapy for von Willebrand disease ( Marinee K.L. Chuah, Inge Petrus, and Thierry VandenDriessche ). Index.