Transduction Mechanisms in Cellular Signaling

Transduction Mechanisms in Cellular Signaling : Cell Signaling Collection

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Description

Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. This title includes articles written and edited by experts in the field. This is a thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses. It features up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease.

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Product details

  • Paperback | 610 pages
  • 216 x 274 x 34mm | 1,700.96g
  • Elsevier Science Publishing Co Inc
  • Academic Press Inc
  • San Diego, United States
  • English
  • Illustrations (some col.)
  • 0123838622
  • 9780123838629
  • 1,483,307

About Edward A Dennis

Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research. Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.

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Table of contents

Volume two includes 183 chapters divided in 8 sections, including: Section A: Protein Phosphorylation 56 Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases 57 Modular Protein Interaction Domains in Cellular Communication 58 Structures of Serine/Threonine and Tyrosine Kinases 59 Protein Tyrosine Kinase Receptor Signaling Overview 60 Signaling by the Platelet-Derived Growth Factor Receptor Family 61 The Epidermal Growth Factor Receptor Family 62 Mechanisms and Functions of Eph Receptor Signaling 63 Cytokine Receptor Signaling 64 The Negative Regulation of JAK/STAT signaling 65 Protein Kinase Inhibitors 66 Integrin Signaling: Cell Migration, Proliferation, and Survival 67 Downstream Signaling Pathways: Modular Interactions 68 Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function 69 Receptor Tyrosine Kinase Signaling and Ubiquitination 70 TGFb Signal Transduction 71 Mitogen-Activated Protein Kinases 72 Recognition of Phospho-Serine/Threonine Phosphorylated Proteins 73 AMP-Activated Protein Kinase 74 Principles of Kinase Regulation 75 Calcium/Calmodulin-Dependent Protein Kinase II 76 Glycogen Synthase Kinase 3 77 The PIKK Family of Protein Kinases 78 Histidine Kinases in Two-Component Signaling Pathways 79 The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases 80 The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana 81 Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors 82 Clinical Applications of Kinase Inhibitors in Solid Tumors 83 Ubiquitin-Mediated Regulation of Protein Kinases in NF?B Signaling 84 Global Analysis of Phosphoregulatory Networks Section B: Protein Dephosphorylation 85 Phosphatase Families Dephosphorylating Serine and Threonine Residues in Proteins 86 The Structure and Topology of Protein Serine/Threonine Phosphatases 87 Naturally Occurring Inhibitors of Protein Serine/Threonine Phosphatases 88 Protein Phosphatase 1 Binding Proteins 89 Protein Serine/Threonine Phosphatase Inhibitors and Human Disease 90 Calcineurin 91 Protein Serine/Threonine-Phosphatase 2C (PP2C) 92 Approaches to the Identification of Protein Tyrosine Phosphatase Substrates 93 Inhibitors of Protein Tyrosine Phosphatases 94 Regulating Receptor PTP Activity 95 CD45

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