- Publisher: Humana Press Inc.
- Format: Hardback | 206 pages
- Dimensions: 160mm x 239mm x 18mm | 544g
- Publication date: 1 October 2009
- Publication City/Country: Totowa, NJ
- ISBN 10: 1607613107
- ISBN 13: 9781607613107
- Edition: 1
- Illustrations note: 33 black & white illustrations, 11 colour illustrations
Thiamine deficiency and related clinical disorders represent an intriguing area of both basic and clinical investigation. Modern imaging strategies have facilitated the rapid treatment, and potential reversal of these clinical disorders. The fusion of laboratory and clinical knowledge serve as an example of how research can translate to successful treatment. The goal of Thiamine Deficiency and Related Clinical Disorders is to bring together cogent results from basic and clinical investigation and to stimulate further investigations in these areas. This data will be useful to neurologists, internists, nutritionists, biochemists, neurochemists, neuroscientists, and others with interest in thiamine deficiency.
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From the reviews: "This short 192 page book Thiamine Deficiency and Associated Clinical Disorders, which is part of the ongoing Contemporary Clinical Neuroscience series, is authored by David McCandless, Ph.D. who is known for his work in metabolic encephalopathy. For those who wish to have a deeper understanding of a number of metabolic derangements which result in neurological dysfunction, this book would be of interest. For the neuroradiologist there is an opportunity to view gross pathology and histopathology ... ." (American Journal of Neuroradiology, October, 2009)
Back cover copy
The past twenty years have seen remarkable advances in neuroscience, neurology, imaging techniques, and diagnostic strategies. These advances have been successfully applied to many different diseases, including thiamine deficiency and associated clinical disorders. Syndromes such as beriberi, Wernicke s disease, Leigh s disease, African Seasonal Ataxia, and various inherited ataxias, have all benefited from improved scientific approaches. Thiamine Deficiency and Associated Clinical Disorders represents an intriguing area of both basic and clinical investigation. Modern imaging and diagnostic strategies have facilitated the rapid treatment, and potential reversal of these clinical disorders. The fusion of laboratory and clinical knowledge serve as an example of how research can translate to successful treatment. This book is designed to bring together cogent results from both basic and clinical investigation. These data will be of interest to neurologists, internists, nutritionists, biochemists, neurochemists, neuroscientists, and many others with interest in thiamine deficiency. About the Author: Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 25th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others. "
Table of contents
Early Chemistry.- Early Thiamine Deficiency.- Thiamine Deficiency in Mammals.- Beriberi.- Wernicke's Disease.- Central Pontine Myelinolysis, Alcoholic Cerebellar Degeneration, and Marchiafava-Bignami Disease.- Leigh's Disease.- African Seasonal Ataxia.- Inherited Ataxias.- Thiamine Deficiency in Serious Illness.- World Health Concerns.- Epilogue: Future Prospects.