Stroke Recovery with Cellular Therapies: Cellular and Genetic Therapies

Stroke Recovery with Cellular Therapies: Cellular and Genetic Therapies

Hardback Current Clinical Neurology

Edited by Daniel M. Rosenbaum, Edited by Sean I. Savitz

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  • Publisher: Humana Press Inc.
  • Format: Hardback | 166 pages
  • Dimensions: 152mm x 231mm x 15mm | 386g
  • Publication date: 1 January 2008
  • Publication City/Country: Totowa, NJ
  • ISBN 10: 1588297322
  • ISBN 13: 9781588297327
  • Edition: 1
  • Illustrations note: 2 black & white tables, biography

Product description

Stroke is the leading cause of serious, long term disability. This book proposes different cellular therapies under investigation to promote neural regeneration after stroke. Authored by an international panel of scientists and clinicians, this volume is a vital, one-of-a-kind resource for all scientists interested in regenerative medicine.

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Back cover copy

As the leading cause of adult disability, stroke poses substantial economic and psychological burdens to populations around the world. Against this dismal backdrop, several novel "neurorestorative" approaches are being investigated as adjunctive treatments to physiotherapy. Stroke Recovery with Cellular Therapies discusses the promising investigations around the world on cell-based therapies to enhance recovery from stroke. Throughout this groundbreaking text, chapters detail the potential benefits of various types of cells and approaches for ischemic and hemorrhagic stroke, and all studies rely upon traditional histological and functional outcomes. Among the topics detailed in this volume are transplanting immortalized neural stem cells, transplantation of bone marrow stromal cells, adipose-derived stem cells, endogenous neural stem cells in tissue remodeling, and an investigation into the ethics of stem cell research. This text provides an overview of the field, stimulates ideas for further research, and will help serve as a foundation for cell-based therapies to move forward as a viable approach for stroke recovery in the future.

Table of contents

Table of Contents: Chapter 1: Introduction The Potential of Cell Transplantation to Enhance Recovery After Stroke Sean I. Savitz, MD Assistant Professor of Neurology Harvard Medical School Boston, MA 02215 Chapter 2 Safety and Efficacy of Transplanting Immortalized Neural Stem Cells in Stroke Patients Lawrence Wechsler, MD Professor of Neurology University of Pittsburgh Medical School Chapter 3 Bone Marrow Transplantation Therapy for Stroke Recovery Michael Chopp, PhD Professor and Vice-Chairman Department of Neurology Henry Ford Health Sciences Center Detroit, MI Chapter 4 Human Umbilical Cord Cells for Stroke Recovery Alison Wiling, PhD Assistant Professor of Neurosurgery Director, Center of Excellence for Aging & Brain Repair University of South Florida College of Medicine Chapter 5 Potential of Adipose-derived Stem Cells for Stroke Henry Rice, MD Associate Professor of Surgery Duke University Medical Center Chapter 6 Novel Imaging Modalities to Monitor Implanted Embryonic Stem Cells in Stroke Mathias Hoehn, PhD Max Planck Institute for Neurological Research Cologne, Germany Chapter 7 Cell Transplantation for Intracerebral Hemorrhage JK Roh, MD Professor of Neurology Seoul National University Hospital Korea Chapter 8 Induction Neurogenesis To Repair The Brain: Do We Need Exogenous Cell Transplantation Mark Mehler, MD Professor of Neurology and Neuroscience Albert Einstein College of Medicine Chapter 9 Ethics of Stem CellTransplantation Ruth Macklin, PhD Professor of Bioethics Department of Epidemiology Albert Einstein College of Medicine Chapter 10 Special Considerations in Clinical Trial Design for Stroke Transplantation Sean I Savitz MD and Louis Caplan, MD Assistant Professor of Neurology and Professor of Neurology Harvard Medical School Beth Israel Deaconess Medical Center