• In-Silico Design and Synthetic Studies of DNA-Gyrase Inhibitors

    In-Silico Design and Synthetic Studies of DNA-Gyrase Inhibitors (Paperback) By (author) Umesh Shiroya, By (author) Sanjay Patel, By (author) Anand Patel

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    DescriptionCoumarins are important class of compounds, isomeric to quinolones. They may become promising candidates for exploiting more useful therapeutically active molecules. DNA-gyrase has drawn much attention as selected target for finding potent anti-bacterial agents against multi-drug resistant strains such as methicillin-resistant Staphyloccus aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-resistant Streptococci pneumonia (PRSP). The objective of the present study was, to study the molecular docking simulations on 5,7-dihydroxy-4-methyl coumarin analogues as probable candidates for inhibiting DNA gyrase subunit-B of S.aureus. In the present study, Docking simulations were carried out on the reported inhibitors of DNA-gyrase subunit A and B using docking software. Based on it, Series of 5,7-dihydroxy-4-methylcoumarin analogues (PH-1 to PH-9) were designed, synthesized, characterized and evaluated for its anti-bacterial activity against S.aureus and E.coli. Out of the nine test compounds, compound PH-4 showed good anti-bacterial activity against S.aureus and E.coli than rest of other compounds.


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    Title
    In-Silico Design and Synthetic Studies of DNA-Gyrase Inhibitors
    Authors and contributors
    By (author) Umesh Shiroya, By (author) Sanjay Patel, By (author) Anand Patel
    Physical properties
    Format: Paperback
    Number of pages: 128
    Width: 152 mm
    Height: 229 mm
    Thickness: 8 mm
    Weight: 200 g
    Language
    English
    ISBN
    ISBN 13: 9783848483075
    ISBN 10: 3848483076
    Classifications

    BIC E4L: HEA
    Nielsen BookScan Product Class 3: S6.2
    Ingram Subject Code: PI
    BIC subject category V2: MMG
    BISAC V2.8: MED071000
    Warengruppen-Systematik des deutschen Buchhandels: 16990
    Illustrations note
    black & white illustrations
    Publisher
    LAP Lambert Academic Publishing
    Imprint name
    LAP Lambert Academic Publishing
    Publication date
    21 April 2012
    Author Information
    I have got M.pharma (Pharmaceutical chemistry) degree from Gujarat Technological University in 2011.I have worked in different areas of Pharmaceutical field. I have published many research and review articles in reputed journals of chemistry.I have depth knowledge of computational, medicinal and organic chemistry.