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Radiation Biology of Medical Imaging

Radiation Biology of Medical Imaging

Hardback

By (author) Philip H. Heintz, By (author) Charles A. Kelsey, By (author) Gregory D. Chambers, By (author) Daniel J. Sandoval, By (author) Natalie L. Adolphi, By (author) Kimberly S. Paffett

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  • Publisher: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
  • Format: Hardback | 320 pages
  • Dimensions: 183mm x 257mm x 23mm | 1,021g
  • Publication date: 21 March 2014
  • Publication City/Country: Chicester
  • ISBN 10: 0470551771
  • ISBN 13: 9780470551776
  • Edition: 1
  • Edition statement: New.
  • Illustrations note: Illustrations (black and white, and colour), 1 map (colour)

Product description

This book provides a thorough yet concise introduction to quantitative radiobiology and radiation physics, particularly the practical and medical application. Beginning with a discussion of the basic science of radiobiology, the book explains the fast processes that initiate damage in irradiated tissue and the kinetic patterns in which such damage is expressed at the cellular level. The final section is presented in a highly practical handbook style and offers application-based discussions in radiation oncology, fractionated radiotherapy, and protracted radiation among others. The text is also supplemented by a Web site.

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Back cover copy

From basic science to contemporary applications--the definitive guide to radiobiology theory and practiceThis book is based on courses taught over many years to individuals preparing for certification or registry examinations to demonstrate their knowledge of radiation and its effects. We also taught CME courses to practicing physicians required to demonstrate their maintained level of competence in radiology and cardiology. Engineers, scientists, and radiation safety specialists also attended many of these courses.Through teaching these classes, we observed that most of our students didn't know or remember much about physics or biology. Practicing physicians and medical professionals were far from current in their knowledge of radiation and its biological effects. We felt a need for a book for the "users" of radiation which would include sections for reviewing basic physics and biology. The authors are a team of scientists and engineers with over a century of combined experience teaching and working with radiation and biology. We are "users" of radiation and mindful of its effects.The first quarter of the book is designed to ensure the reader has a minimum essential knowledge base in biology and physics. The book then covers DNA structure and function, DNA damage and repair, genetic effects, and the characteristics of cancer. The third quarter of the book covers the effects of radiation on various body organs and the entire body as well as effects remote from the site of radiation (the bystander effect). A discussion of the cumulative effect of many small doses of radiation is included. The differences between radiation doses in diagnostic, therapeutic, and nuclear medicine are thoroughly discussed. The last quarter includes chapters describing the effects from medical and natural sources of radiation, while also incorporating a discussion of how regulations are designed to protect workers and the general public from long-term harmful effects. Chapters on the biological effects of MRI and ultrasound are included to complete the book's coverage, although the radiation from an MRI or ultrasound does not produce ionization.Each chapter contains a clear statement of the chapter goals, an extensive body of material with figures and illustrations, and a summary of the important points covered in the chapter. Each chapter concludes with a series of multiple choice questions in the style and level of difficulty of many national examinations.

Table of contents

ACKNOWLEDGMENTS vii INTRODUCTION ix 1 ANATOMY AND PHYSIOLOGY 1 2 THE CELL 19 3 RADIATION CHARACTERISTICS AND UNITS 41 4 RADIATION INTERACTIONS WITH TISSUE 61 5 CELL SURVIVAL CURVES 81 6 DNA AND GENETICS 105 7 RADIATION DAMAGE AND REPAIR OF CELLS 125 8 NORMAL AND MALIGNANT CELLS 145 9 RADIATION EFFECTS ON TISSUES AND ORGANS 161 10 WHOLE BODY RADIATION EFFECTS 179 11 RADIATION TREATMENT OF CANCER 191 12 RADIATION BIOLOGY OF DIAGNOSTIC IMAGING 203 13 NUCLEAR MEDICINE RADIATION BIOLOGY 219 14 ENVIRONMENTAL RADIATION 241 15 REGULATIONS AND RISK 255 16 BIOLOGICAL EFFECTS OF ULTRASOUND 269 17 BIOLOGICAL EFFECTS OF MAGNETIC RESONANCE IMAGING 281 ANSWERS TO ODD-NUMBERED QUESTIONS 297 INDEX 301