Pharmacology: With STUDENT CONSULT Online Access

Pharmacology: With STUDENT CONSULT Online Access

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"Pharmacology" is now established as a worldwide best-selling and highly acclaimed textbook for medical and science students. In this fifth edition, as in the previous four, the approach has been not just to describe what drugs do but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and new ones appear each year. An appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a good starting point for understanding and using the new compound intelligently. Pharmacology is a lively scientific discipline in its own right, with an importance beyond that of providing a basis for the use of drugs in therapy. The book therefore, where appropriate, includes brief coverage of the use of drugs as probes for elucidating cellular and physiological functions, even when the compounds have no clinical uses. The fifth edition retains the short summaries of relevant physiological and biochemical processes placed at the beginning of most chapters to form a basis for the subsequent discussion of pharmacological actions. As before, short sets of key points are placed in boxes throughout the text. These are not intended as comprehensive summaries but rather to highlight pharmacological information that the authors consider important. Factual knowledge in pharmacology is so extensive and expanding so rapidly that students can easily find the information load daunting, and these key points are intended to make it easier for students to gets to grips with the essentials of the subject. As in the previous edition, the therapeutic use of drugs has been given prominence by setting it out in easily identified 'clinical boxes'. For the fifth edition, the book is presented in full colour with a new page format and design. Most diagrams have been updated and all have been redrawn in colour, while many new figures have been added. Continuing the approach used in earlier editions the illustrations, wherever feasible, use real data rather than notional information. As previously, the emphasis is placed on the chemical structures of drugs for where this information helps in understanding how the drugs act. All chapters have been updated and an 'Overview' section has been introduced at the beginning of each to help the reader get a flying start on that topic. In including new material, the book takes into account not only new agents but also recent extensions of basic knowledge which presage further drug development, and, where possible, gives a brief outline of new treatments in the pipeline. New 'small print' sections have been included in many chapters. These contain more detailed, sometimes speculative, material, which can be skipped by the reader in a hurry without losing the main thread, but will be of interest to readers wishing to go into greater depth. As before, the book includes fairly extensive sections on 'References and further reading' at the end of each chapter. Because the medical curriculum stresses project work and the preparation of special study modules, references have been annotated to emphasize the main aspects of their coverage and so make the Reference section easier for students to use.

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Product details

  • Mixed media product | 816 pages
  • 215.9 x 269.2 x 38.1mm | 2,267.99g
  • Elsevier Health Sciences
  • London, United Kingdom
  • English
  • Revised
  • 5th Revised edition
  • 365 ills.
  • 0443071454
  • 9780443071454
  • 1,029,773

Table of contents

I. GENERAL PRINCIPLES 1. What is pharmacology? 2. How drugs act: general principles 3. How drugs act: molecular aspects 4. Cellular mechanisms: excitation, contraction, and secretion 5. Cellular mechanisms: cell proliferation and apoptosis 6. Method and measurement in pharmacology 7. Absorption and distribution of drugs 8. Drug elimination and pharmacokinetics II. CHEMICAL MEDIATORS 9. Chemical mediators and the autonomic nervous system 10. Cholinergic transmission 11. Noradrenergic transmission 12. Other peripheral mediators 13. Peptides and proteins as mediators 14. Nitric oxide 15. Local hormones, inflammation, and immune reactions 16. Anti-inflammatory and immunosuppressant drugs III. DRUGS AFFECTING MAJOR ORGAN SYSTEMS 17. The heart 18. The vascular system 19. Atherosclerosis and lipoprotein metabolism 20. Haemostasis and thrombosis 21. The haemopoietic system 22. The respiratory system 23. The kidney 24. The gastrointestinal tract 25. The endocrine pancreas and the control of blood glucose 26. Obesity 27. The pituitary and adrenal cortex 28. The thyroid 29. The reproductive system 30. Bone metabolism IV. THE NERVOUS SYSTEM 31. Chemical transmission and drug action in the central nervous system 32. Amino acid transmitters 33. Other transmitters and modulators 34. Neurodegenerative disorders 35. General anaesthetic agents 36. Anxiolytic and hypnotic drugs 37. Antipsychotic drugs 38. Drugs used in affective disorders 39. Antiepileptic drugs 40. Analgesic drugs 41. Central nervous system stimulants and psychotomimetic drugs 42. Drug dependence and drug abuse 43. Local anaesthetics V. DRUGS USED IN THE TREATMENT OF INFECTIONS AND CANCER 44. Basic principles of chemotherapy 45. Antibacterial drugs 46. Antiviral drugs 47. Antifungal drugs 48. Antiprotozoal drugs 49. Antihelminthic drugs 50. Cancer chemotherapy VI. SPECIAL TOPICS 51. Individual variation and drug interaction 52. Harmful effects of drugs 53. Gene therapy 54. Drug discovery and development Appendix Index

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Review quote

This is yet another classic book that has become a favourite with medical students across the UK. "Rang et al" provides such a solid basis for first and second year Pharmacology, that you are in some of the safest hands. With marvellous diagrams and "cramming" blue summary boxes, the layout is well thought out and very useful. This book is one of the best you will find. It's especially perfect for during revision."Edinburgh Medics, a Res Medica supplement courtesy of the Royal Medical Society, July 2005"

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