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- Publisher: CHURCHILL LIVINGSTONE
- Format: Paperback | 816 pages
- Dimensions: 2,300g
- Publication date: 24 March 2003
- Publication City/Country: London
- ISBN 10: 0443072027
- ISBN 13: 9780443072024
- Edition statement: 5th ed revised international ed
This textbook for medical and science students emphasises the mechanisms by which drugs act and relates these to the overall pharmacological effects and clinical uses. In doing so it sets out for the reader a clear route from a molecular understanding of receptors and drug actions, to the therapeutic uses of the most important groups of drugs. For the 5th edition the book is presented in full colour with a new page format and design. The text has been fully updated, incorporating significant new information published in the last few years while dated or obsolete material has been removed. New agents are fully discussed as well as extensions of basic knowledge which presage further drug development.
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Table of contents
Section one General principles: What is pharmacology; How drugs act: general principles; How drugs act - molecular aspects; Method and measurement in pharmacology; Absorption and distribution of drugs; Drug elimination and pharmokinetics. Section two cellular processes: Excitable tissues and secretory mechanisms; Cell cycle. Section three: Chemical mediators; Chemical mediators and the autonomic nervous system; Cholinergic transmission; Noradrenergic transmission; Other peripheral mediators: 5-hydroxytryptamine and purines; Peptides and proteins as mediators; Nitric oxide; Local hormones, inflammation and allergy; Anti-inflammatory and immunosuppressant drugs. Section four: Drugs affecting major organ systems; The heart; The vascular system; Atherosclerosis and lipoprotein metabolism; Haemostasis and thrombosis; The haemopoietic system; The respiratory system; The kidney; The gastrointestinal system; The endocrine pancreas and the control of blood glucose; Obesity; The pituitary and adrenal cortex; The thyroid; The reproductive system; Bone metabolism. Section five The nervous system; Chemical transmission and drug action in the central nervous system; Amino acid transmitters; Other transmitters and modulators; Neurodegenerative disorders; General anaesthetic drugs; Anxiolytic and hypnotic drugs; Antipsychotic drugs; Drugs used in affective disorders; Antiepileptic drugs and centrally acting muscle relaxants; Analgesic drugs; Central nervous system stimulants and psychotomimetic drugs; Local anaesthetic drugs. Section six Selective toxicity; Basic principles of chemotherapy; Antibacterial drugs; Antiviral drugs; Antifungal drugs; Antiprotozoal drugs; Anthelminthic drugs; Cancer chemotherapy. Section seven drugs in society; Individual variation and drug interaction; Harmful effects of drugs; Drug dependence and drug abuse; Gene therapy; Drug discovery.