The Origins of Genome Architecture

The Origins of Genome Architecture


By (author) Michael Lynch, By (author) Bruce Walsh

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  • Publisher: Sinauer Associates Inc.,U.S.
  • Format: Hardback | 389 pages
  • Dimensions: 183mm x 239mm x 31mm | 1,225g
  • Publication date: 1 June 2007
  • Publication City/Country: Sunderland
  • ISBN 10: 0878934847
  • ISBN 13: 9780878934843
  • Edition: 1
  • Sales rank: 376,615

Product description

The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features, yet often sacrificing simpler, more compelling explanations. This textbook explains why the details matter and presents an explanatory framework for how the architectural diversity of eukarotic genomes and genes came to arise. Presented in non-technical fashion, it is compatible for use in an advanced Genetics course and as a professional reference.

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Author information

MICHAEL LYNCH is a Distinguished Professor in the Department of Biology at Indiana University, Bloomington, USA. BRUCE WALSH is a Professor in the Department of Ecology and Evolutionary Biology at the University of Arizona, USA.

Review quote

'...the book is likely to create fruitful debates, and be valuable in getting assumptions clear, and helping create a focus on the most important issues, and thus contribute to beginning to understand many aspects of genome evolution.' - Deborah Charlesworth, Genetical Research

Table of contents

The Origin of Eukaryotes Genome Size and Organismal Complexity The Human Genome Why Population Size Matters Three Keys to Chromosomal Integrity The Nucleotide-composition Landscape Mobile Genetic Elements Genomic Expansion by Gene Duplication Genes in Pieces Transcription and Regulatory-region Complexity Expansion and Contraction of Organelle Genomes Sex Chromosome Evolution Genomfart