Oligosaccharides

Oligosaccharides : Their Synthesis and Biological Roles

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Description

Carbohydrates have attracted a great deal of research interest in recent years from both synthetic chemists and glycobiologists. As a result they are now associated with a plethora of important biological processes and have been implicated in the onset and progress of many lethal diseases. They have therefore been identified as novel targets of therapeutic importance. This book, which is aimed at synthetic and medicinal chemists, hopes to introduce both undergraduates and research students to the chemistry and biology of carbohydrates. The book investigates methods for synthesising carbohydrates in a systematic and logical manner and provides real examples from the literature to exemplify the procedures introduced. Both traditional and modern methods for synthesising carbohydrates, including enzymatic and solid-phase techniques, are discussed.

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Product details

  • Paperback | 124 pages
  • 184 x 242 x 100mm | 299.38g
  • Oxford University Press
  • Oxford, United Kingdom
  • English
  • numerous figures
  • 0198502605
  • 9780198502609

Table of contents

CHAPTER 1: INTRODUCTION; Location of oligosaccharides; Therapeutic potential; Nomenclature; Structural representation; Problems associated with oligosaccharide assembly; Further reading; CHAPTER 2: BIOLOGICAL ROLES OF OLIGOSACCHARIDES; Biosynthesis of some biologically important oligosaccharides; Carbohydrates as carriers of biological information; Lectins: Carbohydrate binding proteins; Diseases in which oligosaccharides play an important role; Further reading; CHAPTER 3: SYNTHESIS OF CARBOHYDRATE ACCEPTORS; General introduction to protecting group strategies; Specific protecting group strategies; Selection protection reactions; Synthesis of branched chain oligosaccharides; Further reading; CHAPTER 4: SYNTHESIS OF CARBOHYDRATE DONORS; Glycosyl acetates and thioglycosides; Glycosyl halides; Glycosyl selenides; Trichloroacetimidates; n-Pentyl glycosides; Vinyl glycosides; Glycals; Further reading; CHAPTER 5: ASSEMBLY OF OLIGOSACCHARIDES; Methods to control the configuration of newly formed anomeric bonds; Synthesis of beta-linked mannopyranosides; One pot synthesis of oligosaccharides; Further reading; CHAPTER 6: LITERATURE EXAMPLES OF OLIGOSACCHARIDES; An efficient synthesis of a high mannose type nonasaccharide; Stereoselective construction of the tetrasaccharyl cap portion of Leishmania lipophosphoglycan; A highly convergent synthesis of the tetragalactose moiety of the glycosyl phosphatidyl inositol anchor of the variant surface glycoprotein of Trypanosoma brucei; Synthesis of sialyl-Lewis; Further reading; CHAPTER 7: ALTERNATIVE STRATEGIES FOR SYNTHESISING OLIGOSACCHARIDES; Enzymatic synthesis of oligosaccharides; Polymer supported synthesis of oligosaccharides; Specific examples of polymer supported synthesis; Polymer supported synthesis employing enzymes; Further reading

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