Molecular Biology: Principles and Practice

Molecular Biology: Principles and Practice

Hardback W. H. Freeman

By (author) Michael M. Cox, By (author) Michael O'Donnell, By (author) Jennifer Doudna

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  • Publisher: W.H.Freeman & Co Ltd
  • Format: Hardback | 750 pages
  • Dimensions: 218mm x 278mm x 34mm | 1,982g
  • Publication date: 1 December 2011
  • Publication City/Country: New York
  • ISBN 10: 1464102252
  • ISBN 13: 9781464102257
  • Edition statement: International ed
  • Illustrations note: ill
  • Sales rank: 265,982

Product description

Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped - and who continue to shape - the field today. Key features include: Moment of Discovery Each chapter opens with a description of a significant breakthrough in molecular biology relevant to that chapter, as told by the scientist who made the discovery. They make this a relevant, living subject to students. Examples include: - Joe DeRisi, on his discovery of the SARS virus (Chapter 8) - Melissa Jurica, on her discovery of the first EM structures of spliceosomes (Chapter 16) - Bonnie Bassler, on her discovery of interspecies quorum sensing (Chapter 20) How We Know This end-of-chapter section combines fascinating stories of research and researchers with actual experimental data for students to analyze, often drawing on the work of the scientist featured in the chapter's 'Moment of Discovery.' This ensures the material covered in the book is always shown to be relevant to how scientists really work. Unanswered Questions A short section at the end of each chapter describes important areas still open to discovery, showing students that even well-covered subjects such as nucleic acid structure and DNA replication are far from fully explored. This emphasises the evolving nature of the subject and show students how their work could have impact in the future. Key Conventions These brief paragraphs clearly lay out for student some fundamental principles often glossed over by instructors and textbooks because they are so well understood by professionals. They are helpful to students, who could otherwise be thrown by such assumptions. Highlights Throughout each chapter, special features focus on fascinating topics that enhance student understanding of the concepts: * Medicine looks at diseases that arise from defects in biochemical pathways, or examples of how concepts learned in molecular biology have contributed to drug therapies or other treatments. * Technology focuses on cutting-edge molecular biology methods that students will likely be hearing about or even using in the future. * Evolution reveals the role of molecular biology research in understanding key biological processes and the connections between organisms. * A Closer Look highlights a wide variety of additional, intriguing topics. * Encourages practice and critical thinking End-of-Chapter Problems These give students the opportunity to think about and work with the chapter's key ideas. Each problem set concludes with a Data Analysis Problem, giving students the crucial experience of interpreting real data from actual research (most often the work described in the 'How We Know' section). Solutions to the problems can be found at the end of the book. (This title may not be available in all areas. Please contact your representative for more information.)

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Author information

MICHAEL M. COX is Professor of Biochemistry, University of Wisconsin-Madison, USA. His research focuses on recombinational DNA repair processes. In addition to the work on this text, Cox is a co-author of four editions of Lehninger Principles of Biochemistry. He has received awards for both his teaching and his research, including the 1989 Eli Lilly Award in Biological Chemistry, and two major teaching awards from the University of Wisconsin, USA, and the University of Wisconsin System. JENNIFER A. DOUDNA is Professor of Molecular and Cell Biology and Professor of Chemistry at the University of California, Berkeley, USA, and an Investigator of the Howard Hughes Medical Institute. She has received numerous awards for her research on RNA and RNA-protein structure and function, including the Johnson Foundation Prize for innovative research, the National Academy of Sciences Award for initiatives in research, the Alan T. Waterman Award from the National Science Foundation, and the Eli Lilly Award in Biological Chemistry from the American Chemical Society. MICHAEL O'DONNELL is at the Rockefeller University, USA. He is a member of the National Academy of Sciences.

Table of contents

PART I: FOUNDATIONS Studying the Molecules of Life DNA: The Repository of Biological Information Chemical Basis of Information Molecules Protein Structure Protein Function PART II: NUCLEIC ACID STRUCTURE & METHODS DNA and RNA Structure Studying Genes Genomes, Transcriptomes, and Proteomes Topology: Functional Deformations of DNA Nucleosomes, Chromatin, and Chromosome Structure PART III: INFORMATION TRANSFER DNA Replication DNA Mutation and Repair Moment of Discovery Homologous Recombination Site-Specific Recombination and Transposition DNA-Dependent Synthesis of RNA RNA Processing The Genetic Code Protein Synthesis PART IV: REGULATION Regulating the Flow of Information The Regulation of Gene Expression in Bacteria Transcriptional Regulation of Gene Expression in Eukaryotes Post-Transcriptional Regulation of Gene Expression in Eukaryotes Gene Regulation in Development Online Appendix: Model Organisms