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    Mims' Medical Microbiology (Mosby) (Mixed media product) By (author) Richard Goering, By (author) Hazel Dockrell, By (author) Mark Zuckerman, By (author) Ivan M. Roitt, By (author) Peter L. Chiodini

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    Description"Mims' Microbiology" makes it easy for you to learn the microbiology and basic immunology concepts you need to know for your courses and USMLE. Using a clinically relevant, systems-based approach, this popular medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, "Mims' Microbiology" makes this complex subject simple to understand and remember.


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    Title
    Mims' Medical Microbiology
    Authors and contributors
    By (author) Richard Goering, By (author) Hazel Dockrell, By (author) Mark Zuckerman, By (author) Ivan M. Roitt, By (author) Peter L. Chiodini
    Physical properties
    Format: Mixed media product
    Number of pages: 580
    Width: 218 mm
    Height: 276 mm
    Thickness: 28 mm
    Weight: 1,801 g
    Language
    English
    ISBN
    ISBN 13: 9780723436010
    ISBN 10: 0723436010
    Classifications

    BIC E4L: HEA
    Nielsen BookScan Product Class 3: S6.1T
    B&T Book Type: NF
    Ingram Subject Code: PI
    B&T Modifier: Region of Publication: 01
    B&T General Subject: 510
    B&T Modifier: Academic Level: 02
    Abridged Dewey: 616
    B&T Merchandise Category: MAJ
    B&T Modifier: Text Format: 06
    BIC subject category V2: MMFM, MMF
    Warengruppen-Systematik des deutschen Buchhandels: 16930
    LC classification: QR
    BISAC V2.8: MED052000, MED022090
    DC22: 616.904
    DC23: 616.9041
    Thema V1.0: MKFM, MJCJ
    Edition
    5, Revised
    Edition statement
    5th Revised edition
    Illustrations note
    Approx. 449 illustrations (449 in full color)
    Publisher
    Elsevier Health Sciences
    Imprint name
    Saunders (W.B.) Co Ltd
    Publication date
    06 September 2012
    Publication City/Country
    London
    Table of contents
    Preface v Acknowledgements vi Contributors vi Student Consultants vii A contemporary approach to microbiology xi Microbes and parasites xi The context for contemporary medical microbiology xi Microbiology past, present and future xii The approach adopted in this book xiv SECTION 1 THE ADVERSARIES - MICROBES 1. Microbes as parasites 3 The varieties of microbes 3 Living inside or outside cells 4 Systems of classification 5 2. The bacteria 7 Structure 7 Nutrition 9 Growth and division 10 Gene expression 11 Survival under adverse conditions 16 Mobile genetic elements 16 Mutation and gene transfer 20 The genomics of medically important bacteria 23 3. The viruses 27 Infection of host cells 27 Replication 29 Outcome of viral infection 31 Major groups of viruses 33 4. The fungi 37 Major groups of disease-causing fungi 37 5. The protozoa 41 6. The helminths and arthropods 43 The helminths 43 The arthropods 46 7. Prions 49 'Rogue protein' pathogenesis 49 Development, transmission and diagnosis of prion diseases 50 Prevention and treatment of prion diseases 51 8. The host-parasite relationship 53 The normal flora 53 Symbiotic associations 56 The characteristics of parasitism 58 The evolution of parasitism 59 SECTION 2 THE ADVERSARIES-HOST DEFENCES 9. The innate defences of the body 67 Defence against entry into the body 67 Defences once the microorganism penetrates the body 68 10. Adaptive responses provide a 'quantum leap' in effective defence 83 The role of antibodies 83 The role of T lymphocytes 86 Extracellular attack on large infectious agents 89 Local defences at mucosal surfaces 90 11. The cellular basis of adaptive immune responses 95 B- and T-cell receptors 98 Clonal expansion of lymphocytes 98 The role of memory cells 99 Stimulation of lymphocytes 101 Cytokines 102 Regulatory mechanisms 105 Tolerance mechanisms 106 SECTION 3 THE CONFLICTS 12. Background to the infectious diseases 111 Host-parasite relationships 111 Causes of infectious diseases 115 The biologic response gradient 117 13. Entry, exit and transmission 119 Sites of entry 119 Exit and transmission 125 Types of transmission between humans 127 Transmission from animals 132 14. Immune defences in action 137 Complement 137 Acute phase proteins and pattern recognition receptors 137 Fever 139 Natural killer cells 139 Phagocytosis 139 Cytokines 142 Antibody-mediated immunity 144 Cell-mediated immunity 146 Recovery from infection 149 15. Spread and replication 153 Features of surface and systemic infections 154 Mechanisms of spread through the body 155 Genetic determinants of spread and replication 158 Other factors affecting spread and replication 159 16. Parasite survival strategies and persistent infections 163 Parasite survival strategies 164 Antigenic variation 169 Immunosuppression 170 Persistent infections 173 17. Pathologic consequences of infection 179 Pathology caused directly by microorganism 179 Diarrhea 183 Pathologic activation of natural immune mechanisms 183 Pathologic consequences of the immune response 187 Skin rashes 191 Viruses and cancer 192 SECTION 4 CLINICAL MANIFESTATION AND DIAGNOSIS OF INFECTIONS BY BODY SYSTEM Introduction to Section 4: The clinical manifestations of infection 197 18. Upper respiratory tract infections 199 Rhinitis 199 Pharyngitis and tonsillitis 200 Parotitis 208 Otitis and sinusitis 209 Acute epiglottitis 210 Oral cavity infections 210 19. Lower respiratory tract infections 213 Laryngitis and tracheitis 213 Diphtheria 213 Whooping cough 214 Acute bronchitis 215 Acute exacerbations of chronic bronchitis 216 Bronchiolitis 216 Respiratory syncytial virus infection 216 Hantavirus pulmonary syndrome (HPS) 217 Pneumonia 217 Bacterial pneumonia 218 Viral pneumonia 221 Parainfluenza virus infection 221 Adenovirus infection 223 Human metapneumovirus 223 Human bocavirus 223 Influenza virus infection 223 Severe acute respiratory syndrome-associated coronavirus infection 228 Measles 229 Cytomegalovirus infection 230 Tuberculosis 230 Cystic fibrosis 233 Lung abscess 233 Fungal infections 234 Parasitic infections 235 20. Urinary tract infections 237 Acquisition and aetiology 237 Pathogenesis 238 Clinical features and complications 240 Laboratory diagnosis 241 Treatment 242 Prevention 243 21. Sexually transmitted infections 245 STIs and sexual behaviour 245 Syphilis 245 Gonorrhoea 249 Chlamydial infection 251 Other causes of inguinal lymphadenopathy 253 Mycoplasmas and non-gonococcal urethritis 255 Other causes of vaginitis and urethritis 255 Genital herpes 256 Human papillomavirus infection 257 Human immunodeficiency virus 257 Opportunist STIs 267 Arthropod infestations 267 22. Gastrointestinal tract infections 269 Diarrheal diseases caused by bacterial or viral infection 270 Food poisoning 283 Helicobacter pylori and gastric ulcer disease 284 Parasites and the gastrointestinal tract 284 Systemic infection initiated in the gastrointestinal tract 291 23. Obstetric and perinatal infections 303 Infections occurring in pregnancy 303 Congenital infections 303 Infections occurring around the time of birth 308 24. Central nervous system infections 311 Invasion of the central nervous system 311 The body's response to invasion 311 Meningitis 313 Encephalitis 319 Neurologic diseases of possible viral aetiology 324 Spongiform encephalopathies caused by scrapie-type agents 324 CNS disease caused by parasites 324 Brain abscesses 325 Tetanus and botulism 326 25. Infections of the eye 329 Conjunctivitis 329 Infection of the deeper layers of the eye 332 26. Infections of the skin, soft tissue, muscle and associated systems 335 Bacterial infections of skin, soft tissue and muscle 337 Mycobacterial diseases of the skin 343 Fungal infections of the skin 345 Parasitic infections of the skin 350 Mucocutaneous lesions caused by viruses 351 Smallpox 358 Measles 358 Rubella 360 Other infections producing skin lesions 361 Kawasaki syndrome 361 Viral infections of muscle 361 Parasitic infections of muscle 362 Joint and bone infections 363 Infections of the haemopoietic system 365 27. Vector-borne infections 367 Arbovirus infections 367 Infections caused by rickettsiae 369 Borrelia infections 373 Protozoal infections 375 Helminth infections 380 28. Multisystem zoonoses 383 Arenavirus infections 383 Haemorrhagic fever with renal syndrome (HFRS) 385Marburg and Ebola haemorrhagic fevers 385 Crimean-Congo haemorrhagic fever, a tick-borne virus 385 Q fever 386 Anthrax 386 Plague 387 Yersinia enterocolitica infection 389 Tularemia 389 Pasteurella multocida infection 389 Leptospirosis 389 Rat-bite fever 390 Brucellosis 390 Helminth infections 391 29. Fever of unknown origin 395 Definitions of fever of unknown origin 395 Causes of FUO 395 Investigation of classic FUO 396 Treatment of FUO 399 FUO in specific patient groups 399 Infective endocarditis 400 30. Infections in the compromised host 403 The compromised host 403 Infections of the host with deficient innate immunity due to physical factors 405 Infections associated with secondary adaptive immunodeficiency 408 Other important opportunist pathogens 409 SECTION 5 DIAGNOSIS AND CONTROL 31. Diagnosis of infection and assessment of host defense mechanisms 419 Aims of the clinical microbiology laboratory 419 Specimen processing 419 Non-cultural techniques for the laboratory diagnosis of infection 420 Cultivation (culture) of microorganisms 428 Identification of microorganisms grown in culture 429 Antibody detection methods for the diagnosis of infection 432 Assessment of host defence systems 432 Putting it all together: detection, diagnosis, and epidemiology 436 32. Epidemiology and control of infectious diseases 439 Outcome measurements 439 Types of epidemiological studies 439 Transmission of infectious disease 444 Vaccine efficacy 446 33. Attacking the enemy: antimicrobial agents and chemotherapy 447 Selective toxicity 447 Discovery and design of antimicrobial agents 447 Classification of antibacterial agents 448 Resistance to antibacterial agents 449 Classes of antibacterial agents 452 Inhibitors of cell wall synthesis 452 Inhibitors of protein synthesis 458 Inhibitors of nucleic acid synthesis 465 Antimetabolites affecting nucleic acid synthesis 467 Other agents that affect DNA 469 Inhibitors of cytoplasmic membrane function 469 Urinary tract antiseptics 470 Antituberculosis agents 470 Antibacterial agents in practice 471 Antibiotic assays 473 Antiviral therapy 473 Antifungal agents 481 Antiparasitic agents 483 Control by chemotherapy versus vaccination 483 Control versus eradication 487 Use and misuse of antimicrobial agents 487 34. Protecting the host: vaccination 491 vaccination - A four hundred year history 491 Aims of vaccination 491 Vaccines can be of different types 493 35. Passive and non-specific immunotherapy 505 Passive immunization with antibody 505 Non-specific cellular immunostimulation 508 Correction of host immunodeficiency 509 Probiotics 510 36. Hospital infection, sterilization and disinfection 511 Common hospital infections 511 Important causes of hospital infection 511 Sources and routes of spread of hospital infection 513 Host factors and hospital infection 514 Consequences of hospital infection 515 Prevention of hospital infection 517 Investigating healthcare-associated infection 521 Sterilization and disinfection 526 Online only - Pathogen parade Bibliography 531 Index 539