Medicinal Chemistry: An Introduction

Medicinal Chemistry: An Introduction

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By (author) Dr. Gareth Thomas

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  • Publisher: Wiley-Blackwell (an imprint of John Wiley & Sons Ltd)
  • Format: Paperback | 646 pages
  • Dimensions: 188mm x 244mm x 38mm | 1,220g
  • Publication date: 8 February 2008
  • Publication City/Country: Chicester
  • ISBN 10: 0470025980
  • ISBN 13: 9780470025987
  • Edition: 2, Revised
  • Edition statement: 2nd Revised edition
  • Illustrations note: black & white illustrations, black & white tables, figures
  • Sales rank: 490,643

Product description

Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field. Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. From the reviews of the First Edition: "It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION "Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS

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Medicinal Chemistry, Second Edition provides a comprehensive, balanced introduction to this evolving, multi-disciplinary subject. The book carefully explains fundamental principles, assuming little in the way of prior knowledge. It opens with a broad overview of medicinal assuming little in the way of prior knowledge. It opens with a broad overview of medicinal chemistry followed by chapters that cover the principal methods used in drug design and the isolation of drugs from natural sources. subsequent chapters discuss more specialized aspects of medicinal chemistry and outline drug and analogue synthesis, development and production. Each chapter contains self-assessment questions, numerous examples and a wide variety of applications.Building on the success of the first edition, the book has been completely redesigned to create a clearer, more logical presentation of the material. the text has been extensively revised and updated and includes two new chapters on drugs from natural sources, and drug development and production.Medicinal chemistry, Second Edition will prove invaluable to students of chemistry, medicinal and pharmaceutical chemistry, pharmacy and pharmacology whose courses include medicinal chemistry units.Provides a comprehensive, accessible, clearly written introduction to medicinal chemistryAssumes little prior knowledge of biology and a familiarity with chemistry at first-year levelIncludes numerous examples of drugs and drug actionQuestions are provided at the end of each chapter, with answers at the end of the bookCompletely revised and updated to include many of the latest drugs and treatments

Table of contents

Preface Acknowledgements. Abbreviations. Chapter 1. An Introduction to Drugs, their Action and Discovery. Chapter 2. Drug Structure and Solubility. Chapter 3. Structure-activity and quantitative structures relationships. Chapter 4. Computer aided drug design. Chapter 5. Combinatorial Chemistry. Chapter 6. Drugs from natural sources. Chapter 7. Biological Membranes. Chapter 8. Receptors and Messengers. Chapter 9. Enzymes. Chapter 10. Nucleic Acids. Chapter 11. Pharmacokinetics. Chapter 12. Drug metabolism. Chapter 13. Complexes and chelating agents. Chapter 14. Nitric oxide. Chapter 15. An Introduction to drug and analogue synthesis. Chapter 16. Drug Development and Production. Selective further reading. Answers to Questions. Index.