The Major Histocompatibility System in Man and Animals

The Major Histocompatibility System in Man and Animals


Edited by D. Gotze, Contributions by E. Albert, Contributions by Hans Balner, Contributions by N. Cohen, Contributions by N. H. Collins, Contributions by Chella S. David, Contributions by Martin E. Dorf, Contributions by W. R. Duncan, Contributions by A.F. Geczy, Contributions by D. Gotze

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  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Format: Paperback | 406 pages
  • Dimensions: 155mm x 229mm x 23mm | 612g
  • Publication date: 12 February 2012
  • Publication City/Country: Berlin
  • ISBN 10: 364295295X
  • ISBN 13: 9783642952951
  • Edition statement: Softcover reprint of the original 1st ed. 1977
  • Illustrations note: biography

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Table of contents

Introductory Remarks The Major Histocompatibility System..- 1 The Major Histocompatibility System in Man..- 1. Introduction.- 2. Serologically Defined Histocompatibility Antigens.- 2.1 Historical Remarks.- 2.2 Serology.- 2.3 The Definition of HLA Antigens.- 2.4 The Genetic Organization of HLA-A, B, and C Antigens.- 2.5 Phenotype and Gene Frequencies.- 2.6 Haplotype Frequencies.- 2.7 Linkage Disequilibrium.- 2.8 Cross-Reactivity.- 3. Lymphocyte-Defined Antigens.- 3.1 Historical Remarks.- 3.2 Genetics of MLC.- 3.3 "Primed Lymphocyte Typing".- 4. Serological Definition of B-Cell-Specific Alloantigens.- 4.1 Historical Remarks.- 4.2 Methodology.- 4.3 Genetics of B-Cell Alloantigens.- 5. Cell-Mediated Cytotoxicity.- 5.1 Methodology.- 5.2 Genetics of CML.- 6. Tissue Distribution of HLA Antigens.- 6.1 HLA-A and -B Antigens.- 6.2 HLA-D or Lymphocyte Activating Determinants.- 7. Surface Distribution of HLA Antigens.- 8. Biochemistry.- 8.1 Localization of H Antigens and Source for Their Purification.- 8.2 Assays Monitoring Activity of Soluble HLA Antigens.- 8.3 Extraction Procedures.- 8.4 HLA-A and -B Antigens in the Serum and Urine.- 8.5 HLA-C Antigens.- 9. HLA-D Antigen (B-Cell-Specific, HLA-D Locus-Linked Gene Products).- 10. Linked Loci and Mapping of the HLA Region.- 11. HLA and Transplantation.- 12. HLA-Disease Associations.- 12.1 Historical Remarks.- 12.2 Statistical Considerations.- 12.3 Groups of HLA-Associated Diseases.- 12.4 Models of HLA-Disease Associations.- 12.5 Genetic Considerations.- References.- 2 The Major Histocompatibility System of Subhuman Primate Species..- 1. Introduction.- 2. RhL-A, MHS of Rhesus Monkeys.- 2.1 Detection of Tissue Alloantigens.- 2.2 Biochemistry.- 2.3 Histocompatibility.- 2.4 MHC-Linked Immune Responses.- 2.5 Genetic Organization of the RhL-A System.- 3. ChL-A, the MHS of Chimpanzees.- 3.1 Detection of Tissue Alloantigens.- 3.2 Histocompatibility.- 3.3 Genetic Organization of the ChL-A System.- 4. Tissue Antigens of Other Subhuman Primates.- 4.1 Baboons.- 4.2 Other Primate Species.- 5. Similarities Among Tissue Antigens of Various Primate Species.- 5.1 Similarities Between Alloantigens of Man and Chimpanzee.- 5.2 Similarities Between Alloantigens of Rhesus Monkeys and Those of Other Primate Species.- References.- 3 The Major Histocompatibility System of the Dog..- 1. Introduction.- 1.1 The Dog as an Experimental Model.- 1.2 Short History of Dog Histocompatibility Systems.- 2. DLA Genetics.- 2.1 Nomenclature.- 2.2 Serologically Defined Antigens.- 2.3 Lymphocyte-Defined Antigens.- 2.4 Immune Response Genes.- 2.5 Allogeneic Resistance (R).- 2.6 Other Markers.- 2.7 Genetic Organization of DLA System.- 3. Transplantation Biology of DLA.- 3.1 Related Donor-Recipient Pairs.- 3.2 Unrelated Donor-Recipient Pairs.- 3.3 Blood Transfusions and Graft Survival.- 4. Minor Histocompatibility Systems.- 5. Concluding Remarks.- References.- 4 The Major Histocompatibility System of Cattle, Pig, Rabbit, and Syrian Hamster.- 4.1 The Major Histocompatibility System of Cattle. P. Ivanyi.- 4.1.1 Introduction.- 4.1.2 Blood Cell Chimerism, Immunological Tolerance, and Free Martinism in Cattle Twins.- 4.1.3 The Unknown MHS in Cattle.- 4.1.4 Cattle Alloimmune Sera Cross-Reacting with HLA Antigens.- 4.2 The Major Histocompatibility System of Pig. P. Ivanyi.- 4.2.1 Introduction.- 4.2.2 Blood Group Systems.- 4.2.3 The MHS in Pig: SL-A (SD) or PL-A (LD).- 4.3 The Major Histocompatibility System of Rabbit. P. Ivanyi.- 4.3.1 Introduction.- 4.3.2 Blood Groups and Histocompatibility.- 4.3.3 The Rabbit MHS.- 4.3.4 Rabbits Recognize H-2 and HLA Specificities.- 4.4 The Major Histocompatibility System of Syrian Hamster. W.R. Duncan, J.W. Streilein, and P. Ivanyi.- References.- 5 The Major Histocompatibility System of the Guinea Pig..- 1. Introduction.- 2. Serology.- 2.1 Methodology.- 2.2 Serological Characterization of Antigens Governed by Alleles of the First GPLA Locus (Locus B).- 2.3 Serologic Characterization of Antigens Identified by 13 Anti-2 and 2 Anti-13 Sera.- 2.4 The Identification of an Additional Specificity Present in Inbred Strain 2 and Strain 13 Animals.- 3. Biochemistry.- 4. Histocompatibility.- 5. Genetic Control of the Immune Response by Gene Products from the MHS.- 6. Genetic Organization.- 6.1 Linkage Between the GPLA Locus B and the Ia Region.- 6.2 Products of the Ia Region and GPLA B Locus Represented on the Lymphoid Cells of Wild Guinea Pigs.- References.- 6 The Major Histocompatibility System of the Rat (Ag-B or H-1 System)..- 1. Introduction.- 2. Serogenetics of the H-1 System.- 3. Role of the H-l System in Graft Rejection.- 3.1 Skin Grafts.- 3.2 Organ Grafts.- 3.3 Immunological Enhancement.- 3.4 Other Types of Grafts.- 4. Genetic Control of Mixed Lymphocyte Reactivity by the H-1 System.- 5. Graft-Versus-Host Reactivity and the H-l System.- 6. Features of the Immune Response to H-l Antigens.- 6.1 Thymus Dependence.- 6.2 Quantity of Anti-H-1 Antibodies.- 6.3 Immunological Tolerance to H-1 Antigens.- 6.4 Effect of Preimmunization.- 6.5 "Clone" Size.- 6.6 Antiidiotypic Antibodies.- 7. H-1-Linked Immune Response Genes.- 8. The H-l System and Disease Susceptibility.- 9. Effect of the H-l System on Fetal-Maternal Interactions.- 10. Genetic Structure of the H-1 Chromosome.- 11. Biochemistry of H-l Antigens.- 12. Concluding Remarks.- References.- 7 The Major Histocompatibility System of the Mouse..- 1. Brief History.- 2. Serology.- 2.1 K and D Regions.- 2.2 H-2G Region.- 2.3 I Region.- 2.4 I-J Region.- 2.5 S Region.- 3. Tissue Distribution.- 4. Biochemistry.- 4.1 K and D Products.- 4.2 I Region Antigens.- 4.3 S Region Antigens.- 5. Histocompatibility.- 6. Immune Response.- 6.1 T-Cell, B-Cell Cooperation.- 6.2 Viral Oncogenesis.- 6.3 Mixed Leukocyte Reaction.- 6.4 Graft-Versus-Host Reaction.- 6.5 Cell-Mediated Lympholysis.- 7. Genetic Organization.- 8. Concluding Remarks.- References.- 8 The Major Histocompatibility System of the Chicken..- 1. Introduction.- 2. The B System of the Chicken.- 2.1 Biochemical Characterization of B Antigens.- 2.2 Distribution of B Antigens.- 2.3 Development of B Antigens.- 3. Methods for the Detection of B Antigens.- 3.1 In vitro Demonstration of B Antigens.- 3.2 In vivo Demonstration of B Antigens.- 4. Definition of B Antigens.- 5. Preparation of Antisera.- 6. Chicken Populations Used for the Study of MHS.- 7. MHS in Other Species of Birds.- 8. Conclusions.- References.- 9 Major and Minor Histocompatibility Systems of Ectothermic Vertebrates..- 1. Introduction.- 2. The MHS and the Phylogeny of Transplantation Immunity.- 2.1 Rapidity of First-Set Allograft Reactions: Immunogenetic Considerations.- 2.2 Immunobiology of Major and Minor Histoincompatibility.- 3. The MHS and the Phylogeny of Mixed Lymphocyte Reactivities.- 3.1 Fishes.- 3.2 Amphibians.- 4. The MHS and the Phylogeny of Graft-Versus-Host Reactivities.- 5. Concluding Remarks.- References.- 10 Evolution and Function of the Major Histocompatibility System: Facts and Speculations..- 1. Introduction.- 2. Facts.- 2.1 Genetic Organization.- 2.2 Function.- 2.3 Evolution.- 3. Speculations.- 3.1 Evolution and Function of MHS.- 3.2 Organization of MHS.- 3.3 Relationship of the MHS to Other Loci.- 4. Coda: The Temple of God?.- References.