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    Liver Metastasis: Biology and Clinical Management (Cancer Metastasis - Biology and Treatment) (Paperback) Edited by Pnina Brodt

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    DescriptionLiver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.


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  • Full bibliographic data for Liver Metastasis: Biology and Clinical Management

    Title
    Liver Metastasis: Biology and Clinical Management
    Authors and contributors
    Edited by Pnina Brodt
    Physical properties
    Format: Paperback
    Number of pages: 460
    Width: 155 mm
    Height: 235 mm
    Thickness: 27 mm
    Weight: 689 g
    Language
    English
    ISBN
    ISBN 13: 9789400735453
    ISBN 10: 9400735456
    Classifications

    BIC E4L: HEA
    B&T Book Type: NF
    Nielsen BookScan Product Class 3: S6.2
    Ingram Subject Code: PI
    LC subject heading:
    BIC subject category V2: MJCL
    B&T General Subject: 510
    Abridged Dewey: 616
    LC classification: RC
    B&T Merchandise Category: MAJ
    BISAC V2.8: MED044000
    LC subject heading: ,
    BISAC V2.8: MED030000
    Warengruppen-Systematik des deutschen Buchhandels: 16930
    BIC subject category V2: MJCM
    BISAC V2.8: MED008000
    BIC subject category V2: MMPH
    BISAC V2.8: MED062000, MED085000
    LC subject heading:
    DC21: 614.5999
    BIC subject category V2: MNK
    DC22: 614.5999
    LC classification: R-RZ, RC254-282, RD651-678
    LC subject heading:
    LC classification: R895-920, QR180-189.5, RC261-271
    Thema V1.0: MJCL, MKSH, MJCM, MNK, MKT
    Edition
    13000
    Edition statement
    2011 ed.
    Illustrations note
    biography
    Publisher
    Springer
    Imprint name
    Springer
    Publication date
    21 April 2013
    Publication City/Country
    Dordrecht
    Back cover copy
    Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology. "
    Table of contents
    BIOLOGY. 1. Cellular and molecular aspects of the liver architecture and function. 2. The tumor microenvironment at different stage of hepatic metastasis. 3. The Colorectal Cancer Initiating Cell: Markers and their role of in liver metastasis. 4. Role of CXC chemokines and receptors in liver metastasis - impact on liver resection-induced engraftment and tumor growth. 5. Role of Inflammation in the early stages of liver metastasis. 6. Signal transduction in tumor-endothelial cell communication. 7. Tumor dormancy in liver metastasis: clinical and experimental evidence and implications for treatment. 8. Role of the IGF- axis in liver metastasis: experimental and clinical evidence. 9. Breast Cancer Liver Metastasis. CLINICAL MANAGEMENT.10. Imaging of Hepatic Metastases. 11. Colorectal Carcinoma Liver Metastasis: Surgical Clinical Perspective. 12. Evaluation and Management of Liver Metastases from Non-Gastrointestinal Cancer. 13. Proteomic profiling of hepatic metastases: Paving the way to individualized therapy. 14. Targeting Angiogenesis in the Treatment of Hepatic Metastasis. 15. Uveal melanoma - a paradigm of site-specific liver metastasis.