• Kernicterus

    Kernicterus (Contemporary Clinical Neuroscience) (Paperback) By (author) David W. McCandless

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    DescriptionKernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.

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  • Full bibliographic data for Kernicterus

    Authors and contributors
    By (author) David W. McCandless
    Physical properties
    Format: Paperback
    Number of pages: 300
    Width: 155 mm
    Height: 235 mm
    Thickness: 20 mm
    Weight: 462 g
    ISBN 13: 9781617797019
    ISBN 10: 1617797014

    BIC E4L: HEA
    B&T Book Type: NF
    Nielsen BookScan Product Class 3: S6.2
    LC subject heading:
    BIC subject category V2: MJN
    B&T General Subject: 510
    B&T Merchandise Category: MAJ
    BIC subject category V2: MFGM, PSAN
    LC subject heading: ,
    LC classification: QP
    BISAC V2.8: MED057000
    Warengruppen-Systematik des deutschen Buchhandels: 16930
    BISAC V2.8: MED056000
    LC subject heading:
    Abridged Dewey: 573
    BISAC V2.8: MED060000
    LC classification: QP356.3
    DC23: 616.832
    LC classification: R-RZ, RC346-429.2, RC321-580, RM214-258
    LC subject heading:
    Edition statement
    Illustrations note
    8 black & white tables, biography
    Humana Press Inc.
    Imprint name
    Humana Press Inc.
    Publication date
    25 March 2014
    Publication City/Country
    Totowa, NJ
    Author Information
    Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others
    Review quote
    From the reviews: "Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. ... Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. ... it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus." (Medical Science Books, May, 2011)
    Table of contents
    Dedication page.- Preface.- Acknowledgement.- Key words.-Chapter 1 Prologue: Hyperbilirubinemia, kernicterus, and world health concerns.-Chapter 2 History of bilirubin.-Chapter 3 Biochemistry and physiology of bilirubin.- Chapter 4 Prematurity.- Chapter 5 Erythroblastosis fetalis.- Chapter 6 Gunn rats.- Chapter 7 Crigler-Najjar Syndrome.- Chapter 8 Neuropathology of kernicterus.- Chapter 9 Bilirubin and energy metabolism.- Chapter 10 Bilirubin and other biochemical changes.- Chapter 11 Jaundice and breast milk.- Chapter 12 Jaundice and malaria.- Chapter 13 Jaundice and congenital pyloric stenosis.- Chapter 14 Phototherapy for hyperbilirubinemia.- Chapter 15 Non phototherapy treatment.- Chapter 16 Hyperbilirubinemia revisited.- Chapter 17 Auditory brainstem response.- Chapter 18 Progressive familial intrahepatic cholestasis.- Chapter 19 Kernicterus in older children and adults.- Chapter 20 Cerebral palsy and counseling.- Chapter 21 Neurological sequelae from jaundice.- Chapter 22 Neurobehavioral teratology.- Chapter 23 Gene therapy for hyperbilirubinemia.- Chapter 24 Epilog: Kernicterus: comments and future directions.- Appendix.- References.- Index.