Kernicterus

Kernicterus

US$288.98US$297.55

You save US$8.57

Free delivery worldwide

Available
Dispatched in 4 business days

When will my order arrive?

Kernicterus (bilirubin encephalopathy) is a highly interesting example of metabolic encephalopathy. It fills all the characteristics of a metabolic encephalopathy in that it can develop rapidly, produces signature signs and symptoms, and is amenable to successful treatment. In the absence of treatment kernicterus can produce devastating sequelae and death. The present volume will examine the biochemistry and physiology of bilirubin as well as its hepatic metabolism and renal excretion. Chapters will elaborate bodily disposition of bilirubin and its neuropathology. Both early treatments and current therapy will be discussed in detail. Phototherapy will be presented, and its efficacy and influence on incidence thoroughly examined.

show more
  • Hardback | 300 pages
  • 152.4 x 233.68 x 22.86mm | 612.35g
  • 04 Dec 2010
  • Springer-Verlag New York Inc.
  • New York
  • English
  • 8 black & white tables, biography
  • 1441965548
  • 9781441965547

Other books in this category

Other people who viewed this bought:

Author Information

Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He serves as Editor-in Chief of the journal Metabolic Brain Disease (Springer), now in its 26th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine.Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others

show more

Review quote

From the reviews: "Hyperbilirubinemia and the prevention of development of neurological pathology and/ or death due to kernicterus in newborns is a significant concern for physicians and allied healthcare workers worldwide. ... Kernicterus is a worthy addition to the clinical neuroscience literature as a treatise on a condition that preferentially attacks critical brain regions. ... it should be read widely by clinicians and public health officers confronted by issues related to the early diagnosis, treatment and rehabilitation of individuals suffering from kernicterus." (Medical Science Books, May, 2011)

show more

Back cover copy

"Kernicterus" is an excellent example of a metabolic encephalopathy. It clearly produces a biochemical lesion early when bilirubin first enters the brain. If initial staining can be minimized or reversed, permanent damage can be avoided. This takes strict attention to detail, and a keen ability for timely and accurate diagnosis. The potential for improvement/reversal argues strongly for increased awareness by all health care workers. "Kernicterus" will examine the history, biochemistry, physiology, neuropathology, etc., of bilirubin. New concepts of how bilirubin is toxic, and damages the acoustic system will be thoroughly examined. The promising new treatment possibility using gene therapy will be examined in detail. This therapy has been successfully used in the excellent animal model, the Gunn rat. Translation of these exciting results to newborn infants is well underway. About the Author: Dr. David W. McCandless is the John J. Sheinin Professor of Anatomy in the Department of Cell Biology and Anatomy at The Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA. He has over 35 years of laboratory research into basic mechanisms of various metabolic encephalopathies. He is the Founding Editor of the journal Metabolic Brain Disease (Springer), now in its 27th year. Dr. McCandless has been on the faculty or research staff at The University of Vermont College of Medicine, NIH-NINCDS, University of Texas Medical School at Houston, and The Chicago Medical School, and was a visiting professor at Washington University School of Medicine. Dr. McCandless has published in journals such as The J. Clinical Investigation, Nature, Proc. National Academy of Sciences, Amer. J. of Physiology, Brain Research, J. Neurochemistry, Teratology, Epilepsia, Stroke, and many others.

show more