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    An Introduction to Medicinal Chemistry (Paperback) By (author) Graham L. Patrick

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    DescriptionAn Introduction to Medicinal Chemistry is the leading text for university courses on this subject. Renowned for being a textbook loved equally by both students and lecturers, it presents complete coverage in an accessible and engaging style. The text begins with the essential biochemistry on which an understanding of medicinal chemistry is built, introducing the structure and function of important drug targets. It then explores how drugs interact with the body and the consequences of those reactions. There is a section on general principles and strategies involved in discovering and designing new drugs, and another on useful 'tools of the trade'. The text ends with a contemporary look at specific topics within medicinal chemistry, for example, antiviral and anticancer agents; cholinergics and anticholinesterases; and antiulcer agents. Learning features throughout An Introduction to Medicinal Chemistry help to unlock this fascinating subject. A glossary helps to familiarise the language of medicinal chemistry. Boxes present in-depth material and explore how concepts are applied in practice. Key points summarise sections within chapters, providing a basis for revision, and questions at the end of chapters and on the accompanying Online Resource Centre allow the reader to test their understanding and develop molecular modelling skills. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: * Answers to end-of-chapter questions * Figures from the book * Power Point slides * Test Bank questions For students: * Multiple Choice Questions * Web articles * Molecular Modelling Exercises * 3D Rotatable structures

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  • Full bibliographic data for An Introduction to Medicinal Chemistry

    An Introduction to Medicinal Chemistry
    Authors and contributors
    By (author) Graham L. Patrick
    Physical properties
    Format: Paperback
    Number of pages: 816
    Width: 196 mm
    Height: 264 mm
    Thickness: 44 mm
    Weight: 1,461 g
    ISBN 13: 9780199697397
    ISBN 10: 0199697396

    BIC E4L: HEA
    Nielsen BookScan Product Class 3: S6.1T
    B&T Book Type: NF
    B&T Modifier: Region of Publication: 03
    BIC subject category V2: MMG
    B&T Modifier: Subject Development: 43
    Ingram Subject Code: SE
    B&T General Subject: 510
    Warengruppen-Systematik des deutschen Buchhandels: 16920
    B&T Modifier: Academic Level: 02
    B&T Merchandise Category: MAJ
    B&T Modifier: Text Format: 06
    BIC subject category V2: TDCW
    LC subject heading:
    BISAC V2.8: MED072000, SCI013000
    B&T Approval Code: A65230000
    LC subject heading:
    DC22: 615.1/9
    Libri: CHEM0450
    DC23: 615.19
    LC classification: RS403 .P38 2013
    Thema V1.0: TDC, MKG
    5, Revised
    Edition statement
    5th Revised edition
    Illustrations note
    1100 colour line drawings
    Oxford University Press
    Imprint name
    Oxford University Press
    Publication date
    01 October 2013
    Publication City/Country
    Author Information
    Dr. Graham Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemist on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants. His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of Paisley (now the University of the West of Scotland) in 1990, teaching medicinal chemistry and drug design.
    Review quote
    There is no comparable book... the holy grail for a pharmaceutical science-based course. Doody's Notes, May 2013
    Table of contents
    1. Drugs and drug targets - an overview ; PART A DRUG TARGETS- STRUCTURE AND FUNCTION ; 2. Protein structure and function ; 3. Enzymes: structure and function ; 4. Receptors: structure and function ; 5. Receptors and signal transduction ; 6. Nucleic acids: structure and function ; PART B PHARMACODYNAMICS AND PHARMACOKINETICS ; 7. Enzymes as drug targets ; 8. Receptors as drug targets ; 9. Nucleic acids as drug targets ; 10. Miscellaneous drug targets ; 11. Pharmacokinetics and related topics ; Case study 1: Statins ; PART C DRUG DISCOVERY, DESIGN, AND DEVELOPMENT ; 12. Drug discovery: finding a lead ; 13. Drug design: optimizing target interactions ; 14. Drug design: optimizing access to the target ; 15. Getting the drug to market ; Case study 2: The design of ACE inhibitors ; Case study 3: Artemisinin and related antimalarial drugs ; Case study 4 : The design of oxamniquine ; PART D TOOLS OF THE TRADE ; 16. Combinatorial synthesis ; 17. Computers in medicinal chemistry ; 18. Quantitative structure-activity relationships (QSAR) ; Case study 5: De novo design of a thymidylate synthase inhibitor ; PART E SELECTED TOPICS IN MEDICINAL CHEMISTRY ; 19. Antibacterial agents ; 20. Antiviral agents ; 21. Anticancer agents ; 22. Cholinergics, anticholinergics, and anticholinesterases ; 23. Drugs acting on the adrenergic nervous system ; 24. Opioid analgesics ; 25. Antiulcer agents ; Case study 6: Steroidal anti-inflammatory agents ; Case Study 7: Design of a novel antidepressant ; APPENDICES