Immunology of Gene Therapy

Immunology of Gene Therapy


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* Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic* Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases* Broad appeal - applicable for immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research

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Product details

  • Hardback | 398 pages
  • 160.02 x 233.68 x 25.4mm | 680.39g
  • John Wiley and Sons Ltd
  • Wiley-Blackwell
  • Hoboken, United States
  • English
  • 0470134062
  • 9780470134061

Review quote

"This book provides a thorough and comprehensive description of the problems faced by gene therapists, and their continuing need to overcome the immune system to allow effective gene therapy in future clinical trials. It is well placed to be a useful and informative textbook, which I would highly recommend." ( Immunology News , May 2009) "This book, put together by experts, delivers a fresh approach to thinking about gene therapy and delivery of the vectors. The information is as current as a multiauthored book can be and would be useful to students as well as physicians." ( Doody's Reviews , March 2009)

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Back cover copy

The first comprehensive reviewof the immunologyof gene transfer Gene Therapy Immunology is the first book of its kind to summarize and present a broad review of the latest immunological advances in the field of genetic therapy. The book's unique organization, which approaches the topic from a vector and target organ point of view, rather than from a disease-specific perspective, reflects the ways in which gene therapies are being investigated today. This provides scientists and physicians attempting to develop gene therapies with a powerful tool for comparing vectors and target organs side by side, making the right investigative and clinical choices, anticipating potential problems, modifying protocols, and obtaining a broader view of the issues. Each chapter covers local and systemic responses; strengths and characteristics of innate responses; strengths and characteristics of adaptive (i.e., T helper, cytotoxic T lymphocyte, and B cell/antibody) responses to the vector and to transgene products; and preexisting immunity in humans. Authored by internationally renowned researchers and clinicians and edited by the former chair of the Immunology Committee of the American Society for Gene Therapy, this book is an indispensable resource for scientists, physicians, and students who work in gene therapy. It is also a valuable text for advanced undergraduate and graduate courses on immunology.

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Table of contents

1. The immunology of gene transfer: an overview (David Lillicrap). 2. Innate immune responses to nucleic acids (Ishii and Akira). 3. The anti-viral Innate immune response (Daniel Muruve). U. Calgary, Canada. 4. Immune responses to adenoviral vectors (Dmitry M. Shayakhmetov). 5. Immune responses to lentiviral vectors (Lung-Ji Chang). 6. Immune responses to adeno-associated virus vectors (Hildegund Ertl). 7. Immunology after in utero and neonatal gene transfer (Simon Waddington). 8. Immunology of hepatic gene transfer (Roland Herzog). 9. Immune responses to adenoviral, AAV, and lentiviral vector used for gene therapy of brain diseases (Pedro Lowenstein). 10. Immunology of cutaneous gene transfer (Soosan Ghazizadeh). 11. Immune responses to pulmonary gene therapy (Terence Flotte). 12. Induction of immune tolerance through gene transfer to hematopoietic stem cells (John Iacomini). 13. Reconstitution of the immune system by gene therapy (Adrian Thasher). 14. Genetics of the Immune Response to Proteins Expressed After Gene Transfer (Jay Lozier). 15. Immune modulation and transient suppression strategies (Valder Arruda). 16. Gene therapy for autoimmune diseases (Nicholas Giannoukakis). 17. Engineering of viral capsids to evade the host immune system (. Hildegard Buning).

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