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- Publisher: John Wiley & Sons Inc
- Format: Hardback | 434 pages
- Dimensions: 36mm x 55mm 850g
- Publication date: 10 May 1990
- Publication City/Country: New York
- ISBN 10: 0471567302
- ISBN 13: 9780471567301
- Illustrations note: Ill.
Human retrovirology is a rapidly advancing area of inquiry in medical microbiology and the study of infectious disease. This volume features recent information on human T cell leukemia viruses type 1 and 2 and on the two immunodeficiency-causing retroviruses, HIV-1 and HIV-2. In addition, it presents exploratory data on animal models of human retroviruses and the search for human retroviruses associated with multiple sclerosis and systemic lupus erythrematosis. The molecular biology of HTLV-1 is detailed, particularly the functions of the tax and rex proteins which have become a major focus, not only for the understanding of the function of this virus but also as models of gene regulation in eukaryotic cells. Similiarly, the molecular genetics and functional role products of HIV-1 and 2 are discussed at length.
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Table of contents
Partial table of contents:; MOLECULAR BIOLOGY OF HTLV; Control of Cellular and HTLV-I Gene Expression by Regulatory Genes (Tax and Rex) (M. Yoshida, et al.); Molecular Analysis of Trans-Activation in the HTLV-I LTR (S. Marriott, et al.); MOLECULAR BIOLOGY OF HIV; Functional and Structural Domains of the Human Immunodeficiency Virus Transacting Regulatory Proteins Tat and Rev (A. Cochrane, et al.); Transcriptional Regulation of HIV (B. Peterlin); VIRUS-CELL INTERACTIONS; Analysis of the HIV Envelope Binding Domain on CD4 Through Site-Directed Mutagenesis (J. Arthros, et al.); The Biologic Heterogeneity of HIV and the Pathogenesis of AIDS (J. Levy, et al.); STRATEGIES FOR VACCINE AND TREATMENT; Strategy of Targeted Antiretroviral Therapy Against Human Immunodeficiency Virus (HIV) (H. Mitsuya, et al.); Protection of Rabbits against HTLV-I Infection by Passive Immunization (N. Takehara, et al.); THE SEARCH FOR NEW HUMAN RETROVIRUSES; Evidence for the Involvement of Retroviruses in the Pathogenesis of Systemic Lupus Erythematosus (W. Leitmann, et al.); Evidence for Homologous Retroviral Sequences in Multiple Sclerosis by Enzymatic Gene Amplification (G. Ehrlich, et al.); Index.