• Gene Therapy for Renal Diseases and Transplantation See large image

    Gene Therapy for Renal Diseases and Transplantation (Contributions to Nephrology) (Hardback) Edited by Giuseppe Remuzzi, Edited by A. Benigni, Series edited by C. Ronco

    Hard to find title available from Book Depository

    $218.73 - Free delivery worldwide Available
    Dispatched in 3 business days
    When will my order arrive?
    Add to basket | Add to wishlist |

    DescriptionInitially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. In the present book, world-renowned experts are presenting new insights into viral and non-viral systems used to effect gene delivery, one chapter being dedicated to the new field of RNA interference (RNAi). This latter method may be successfully used in renal ischemia-reperfusion injury, trauma and transplantation. In the near future, gene therapy might also prove to be a new strategy to target molecules involved in tissue damage and inflammation processes that underlie ARF. So far, gene transfer has been successfully applied in experimental glomerulonephritis and interstitial fibrosis, and studies in larger animals are keenly awaited.Also covered are issues related to transplantation, which is the therapy of choice in many end-stage organ failures. Transfer of genes whose protein products have immunomodulatory properties have proven beneficial in treating acute and chronic graft rejection, one of the problems not satisfactorily solved by current anti-rejection drugs. Gene therapy thus may become a reality in clinical transplantation once its efficacy in larger animals has been demonstrated. Last but not least, a possible benefit of targeted gene therapy in renal cancer or HIV-associated nephropathy is explored. Covering a wide spectrum of topics, this publication provides a valuable overview of current developments and issues.

Other books

Other people who viewed this bought | Other books in this category
Showing items 1 to 10 of 10


Reviews | Bibliographic data
  • Full bibliographic data for Gene Therapy for Renal Diseases and Transplantation

    Gene Therapy for Renal Diseases and Transplantation
    Authors and contributors
    Edited by Giuseppe Remuzzi, Edited by A. Benigni, Series edited by C. Ronco
    Physical properties
    Format: Hardback
    Number of pages: 168
    Width: 173 mm
    Height: 244 mm
    Thickness: 13 mm
    Weight: 499 g
    ISBN 13: 9783805585057
    ISBN 10: 3805585055

    Warengruppen-Systematik des deutschen Buchhandels: 16960
    BIC E4L: HEA
    B&T Book Type: NF
    Nielsen BookScan Product Class 3: S6.2
    LC subject heading:
    B&T Modifier: Text Format: 02
    B&T General Subject: 510
    B&T Modifier: Region of Publication: 04
    B&T Merchandise Category: MAJ
    B&T Modifier: Academic Level: 03
    BIC subject category V2: MJR
    BISAC V2.8: MED055000
    Libri: NEPH5000, NIER5000, RENA5000
    DC22: 616.61042
    LC subject heading:
    BIC subject category V2: MJZ
    LC subject heading: ,
    DC22: 616.6/1042
    LC subject heading: , , ,
    LC classification: RC903 .G43 2008
    LC subject heading: ,
    Thema V1.0: MJR, MKZV
    Illustrations note
    15, in Color:4 Tables:6
    S Karger Ag
    Imprint name
    S Karger Ag
    Publication date
    01 May 2008
    Publication City/Country
    Table of contents
    Preface: Benigni, A.; Remuzzi, G.; Renal Diseases as Targets of Gene Therapy: Phillips, B.; Giannoukakis, N.; Trucco, M.; Nonviral Gene Delivery: Akita, H.; Harashima, H.; Retrovirus Vectors: Lech, P.; Somia, N.V.; Adenovirus Vectors for Renal-Targeted Gene Delivery: Appledorn, D.M.; Seregin, S.; Amalfitano, A.; Adeno-Associated Virus Vectors: Versatile Tools for in vivo Gene Transfer: Zentilin, L.; Giacca, M.; RNA Interference in Research and Therapy of Renal Diseases: Racz, Z.; Hamar, P.; Gene Therapy for Acute Renal Failure: Torras, J.; Cruzado, J.M.; Herrero-Fresneda, I.; Grinyo, J.M.; Chronic Deteriorating Renal Function and Renal Fibrosis: Isaka, Y.; Takahara, S.; Imai, E.; Allograft Rejection: Acute and Chronic Studies: Tomasoni, S.; Remuzzi, G.; Benigni, A.; Gene Therapy for Renal Cancer: Haviv, Y.S.; Curiel, D.T.; HIV-Associated Nephropathy: Wyatt, C.M.; Rosenstiel, P.E.; Klotman, P.E.