Edited by C. David Allis, Edited by Thomas Jenuwein, Edited by Danny Reinberg, Edited by Marie-Laure Caparros

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  • Publisher: Cold Spring Harbor Laboratory Press,U.S.
  • Format: Paperback | 502 pages
  • Dimensions: 211mm x 277mm x 25mm | 1,338g
  • Publication date: 15 January 2009
  • Publication City/Country: New York
  • ISBN 10: 0879698756
  • ISBN 13: 9780879698751
  • Illustrations note: colour illustrations, black & white tables, figures
  • Sales rank: 455,466

Product description

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

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Review quote

"In addition to the cutting-edge epigenetic research that is highlighted in this book by eminent scientists in the field, the summaries at the beginning of each chapter, and the multiple tables and colourful illustrations used throughout the book will prove useful in guiding the reader through a discussion of complex biological processes. Undoubtedly, some of these illustrations will be widely used by students and teachers of epigenetics."