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Development of Self Microemulsifying Drug Delivery System

Development of Self Microemulsifying Drug Delivery System

Paperback

By (author) MR Maulik Patel, By (author) Dr Sanjay Patel, By (author) Dr Natvarlal

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  • Publisher: LAP Lambert Academic Publishing
  • Format: Paperback | 104 pages
  • Dimensions: 150mm x 220mm x 6mm | 204g
  • Publication date: 1 June 2011
  • Publication City/Country: Saarbrucken
  • ISBN 10: 3844331824
  • ISBN 13: 9783844331820
  • Illustrations note: black & white illustrations

Product description

Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate of the drug. However, these methods have their own limitations. In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drugs. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self-microemulsifying drug delivery systems (SMEDDS).

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Author information

Mr. Maulik J. Patel (Assistant Professor, Pharmaceutics Department), Dr. Sanjay S. Patel, (Associate Professor, Pharmaceutics Department) and Dr. Natvarlal M. Patel (Principal) working in Shri B. M. Shah College of Pharmaceutical Education and Research, Modasa - 383315, India