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    Comprehensive Biomarker Discovery and Validation for Clinical Application (Rsc Drug Discovery) (Hardback) Edited by Peter Horvatovich, Edited by Rainer Bischoff, Series edited by David E. Thurston, Series edited by David Fox, Series edited by David P. Rotella, Series edited by Ana Martinez, Series edited by Salvatore Guccione, Series edited by Professor Robin Ganellin, Contributions by Isabelle Fournier, Contributions by Eleftherios P. Diamandis

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    DescriptionComprehensive Biomarker Discovery and Validation for Clinical Application provides the reader with an extensive introduction into all aspects of proteomics biomarker discovery, validation and development. It discusses the current status of science and technology, its limitations, bottlenecks as well as future development trends to improve the success rate of translating biomarker discovery into useful clinical tests. The most important feature of the book is to provide an overview of current technologies and the challenges encountered during biomarker discovery and validation, such as patient selection, sample handling, data processing, statistical analysis and registration and approval of validated biomarkers through European and US regulatory authorities. The authors introduce the reader to each of these topics in significant detail and provide examples or guidelines for best practice. There are prominent chapters included on biomarkers in translational and personalised medicine; an introduction to regulatory affairs and bring biomarkers to the market; biomarker discovery and the use of mass spectrometry based profiling platforms; MALDI imaging techniques in tissue-based biomarkers discovery and a clinical application study on the use of diagnostic assays for early diagnosis of heart failure using various proteomic methods. The book concludes with a final chapter on future trends in biomarker discovery and validation. The book targets a readership of industrial and academic researchers that are involved in biomarker discovery and validation or that manage biobanks, develop sample preparation methods, analytical profiling systems and bioinformatics tools. Common pitfalls and success stories in biomarker discovery are highlighted and guidelines for best practice are provided for the different parts of the procedure. The book will be an essential information resource for scientists working in the field.


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    Title
    Comprehensive Biomarker Discovery and Validation for Clinical Application
    Authors and contributors
    Edited by Peter Horvatovich, Edited by Rainer Bischoff, Series edited by David E. Thurston, Series edited by David Fox, Series edited by David P. Rotella, Series edited by Ana Martinez, Series edited by Salvatore Guccione, Series edited by Professor Robin Ganellin, Contributions by Isabelle Fournier, Contributions by Eleftherios P. Diamandis
    Physical properties
    Format: Hardback
    Number of pages: 384
    Width: 156 mm
    Height: 234 mm
    Thickness: 28 mm
    Weight: 720 g
    Language
    English
    ISBN
    ISBN 13: 9781849734226
    ISBN 10: 1849734224
    Classifications

    BIC E4L: HEA
    B&T Book Type: NF
    Nielsen BookScan Product Class 3: S6.2
    B&T Modifier: Region of Publication: 01
    BIC subject category V2: MMG
    Ingram Subject Code: SE
    Libri: I-SE
    B&T Merchandise Category: SCI
    B&T General Subject: 710
    B&T Modifier: Text Format: 02
    B&T Modifier: Academic Level: 02
    BIC subject category V2: PSB
    Abridged Dewey: 572
    BIC subject category V2: MJA
    LC classification: QP
    BIC subject category V2: MBGL
    Warengruppen-Systematik des deutschen Buchhandels: 16930
    BISAC V2.8: SCI007000
    DC23: 616.0756
    Thema V1.0: PSB, MKG, MBGL, MJA
    Illustrations note
    20 colour illustrations, 100 black & white illustrations
    Publisher
    Royal Society Of Chemistry
    Imprint name
    Royal Society Of Chemistry
    Publication date
    10 June 2013
    Publication City/Country
    Cambridge
    Author Information
    Peter Horvatovich and Rainer Bischoff have worked at the University of Groningen Faculty of Mathematics and Natural Science for more than five years. Rainer Bischoff is professor in analytical biochemistry and has been studying protein analysis and proteomics for over 20 years. He obtained his PhD at the University of G/ttingen before undertaking postdoctoral research at Purdue University in the USA. He also worked as a group and project leader at Transgene S. A. in Strasburg and a section manager at AstraZeneca R&D in Lund. Peter Horvatovich is an Assistant Professor. He has studied proteomics related bioinformatics for more than eight years and has an analytical chemistry background. Dr Horvatovich received his PhD at the University of Strasbourg for work related to the detection of irradiated food. He then worked at Sanofi-Synthelabo in Budapest and as a postdoctoral researcher at the Bundesinstitute fur Risikobewertung in Berlin before moving to the University of Groningen.
    Back cover copy
    This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (EMEA and FDA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of different LC-MS profiling platforms and affinity array for screening complex body fluids. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers.
    Table of contents
    Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends