Classics in Total Synthesis: Targets, Strategies, Methods

Classics in Total Synthesis: Targets, Strategies, Methods


By (author) K. C. Nicolaou, By (author) E. Sorenson

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  • Publisher: Wiley-VCH Verlag GmbH
  • Format: Paperback | 821 pages
  • Dimensions: 190mm x 250mm x 40mm | 1,940g
  • Publication date: 11 April 1996
  • Publication City/Country: Weinheim
  • ISBN 10: 3527292314
  • ISBN 13: 9783527292318
  • Illustrations note: 444 b&w figures, 1 table
  • Sales rank: 421,225

Product description

A presentation of total syntheses from organic chemists, analyzing each retrosynthetically to make strategies more accessible. The authors give hints on alternative methods and potential pitfalls. Emphasis is placed on the use of graphics and schemes: reaction sequences and synthetically crucial steps are presented in blue boxed sections; important formulas are, in addition, depicted in the margin, next to the passage where they are mentioned in the text.

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Back cover copy

K. C. Nicolaou, E. J. Sorensen Classics in Total Synthesis Targets, Strategies, Methods This book is a must for every synthetic organic chemist. With didactic skill and clarity, K. C. Nicolaou and E. J. Sorensen present the most remarkable and ingenious total syntheses from the laboratories of some of the world's greatest synthetic organic chemists. To make the strategies more understandable and accessible, especially to the novice, each total synthesis is first analyzed retrosynthetically. The authors then carefully describe each step and comment on alternative methods and potential pitfalls. When appropriate, key chemical reactions are discussed in the wider context of the chemical literature, giving the reader a lesson in both total synthesis and synthetic methods. Diverse structural types of natural products and important organic transformations including pericyclic, ionic, radical, and photochemical reactions are covered. Catalysis, asymmetric synthesis, organometallic chemistry, and cyclization reactions are especially highlighted. Mechanism, reactivity, selectivity, and stereochemistry are presented clearly and discussed analytically. Numerous references to useful reviews and the original literature will make this book the first point of entry into the vast field of synthetic organic chemistry. Special emphasis is placed on the skillful use of graphics and schemes. Retrosynthetic analyses, reaction sequences and crucial synthetic steps are presented in boxed, blue background sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students, teachers, and researchers alike will find this book to be a gold mine of useful information. Every synthetic chemist will have a copy on his or her desk.

Table of contents

Constructing the molecules of nature; strychnine; penicillin; reserpine; prostaglandin F2a and E2; progesterone; carpanone; Vitamin B12; prostaglandin A2 and F2a; estrone; erythronolide B; monensin; periplanone B; isocomene; monensin; thienamycin; endiandric acids; biotin; L-hexoses; asteltoxin; periplanone B; menthol; amphoteronolide B and amphotericin B; ginkgolide B; methyl homosecodaphniphllate; indolizomycin; cytovaricin; gilvocarcin M and V; rapamycin; paeoniflorigenin and paeoniflorin; strychnine; taxol; zaragozic acid A / squalestatin S1; palytoxin; brevetoxin B. (Part contents).