Chemistry and Biology of Serpins

Chemistry and Biology of Serpins


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Serpins (serine protease inhibitors) are a superfamily of proteins whose physiologi- cal action is primarily targeted to inhibiting serine proteases. There are instances where serpins are not inhibitors (and can carry steroid hormones for instance), yet key structural and functional elements found in all serpins are maintained in these 'non-inhibitor' ser- pins. Many serpins have well-described biological properties which influence pathophysi- ological events, including: antithrombin (historically called antithrombin III), ai-protease inhibitor (historically called ai-antitrypsin), and plasminogen activator inhibitor-I, just to mention a few. A deficiency or defect in antithrombin leads to venous thromboembolic disease, while a deficiency or defect in ai-protease inhibitor is associated with chronic obstructive pulmonary emphysema. In contrast, it has been suggested that increased levels of plasminogen activator inhibitor-l may be a predisposition to myocardial infarction. The list goes on for each of our own "favorite" serpin. The biological roles found for serpins are key participants in almost every physiological event. In other words, serine proteases are needed for many events in biology and the role of serpins to down regulate these pro- teases is essential. Thus, just using these three examples above for serpins and their patho- physiological roles reminds us that the medical costs to control such events is significant worldwide.

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  • Paperback | 358 pages
  • 178.05 x 254 x 21.84mm | 721.21g
  • Springer-Verlag New York Inc.
  • New York, NYUnited States
  • English
  • Softcover reprint of the original 1st ed. 1997
  • biography
  • 1461374618
  • 9781461374619

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'The editors have succeeded in producing a volume of work which provides many answers to questions, asked and unasked, about a critically important field of biologic research. It should be in the library of any scientist with an interest in human physiology; it would be useful to many other researchers as well.' Chemtracts - Biochemistry and Molecular Biology, 12:10 (1999)

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