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    Cancer Biotherapy: An Introductory Guide (Paperback) Edited by David Kerr, Edited by Lewis Rowett, Edited by Annie Young

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    DescriptionRecent advances in biology and immunology have opened up new horizons in both our understanding of cancer as a disease, and the potential for cancer therapy. These major developments mean that chemotherapy, radiotherapy and surgery are no longer the only options. Biotherapy, or biological therapy, is now regarded as the fourth treatment modality for patients with cancer. It utilises the great increase in our knowledge of molecular biology, cell biology and immunology to achieve tumour control. New biological agents are currently being used to treat cancer, such as monoclonal antibodies and vaccine therapies to stimulate the body's immune system to attack cancer cells. Biotherapy may be targeted to act specifically on cancer cells. Drugs such as monoclonal antibodies can be designed to recognize and find a particular type of cancer cell, attach itself to them, and destroy them. Naturally occuring biological molecules such as cytokines are also used, and the manipulation of normal biological mechanisms to control or inhibit tumour growth is another key feature of biotherapy. Edited by a team with perspectives in pharmacology, oncology and nursing, and with contributions from experts in the various areas of biotherapy, this book serves as an introduction to the subject. It includes the principles behind biological therapy, with discussion of the impact on the future of the fight against cancer. It has a strong clinical focus, describing the relevant biology and immunology while highlighting clinical relevance and treatment issues.


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  • Full bibliographic data for Cancer Biotherapy

    Title
    Cancer Biotherapy
    Subtitle
    An Introductory Guide
    Authors and contributors
    Edited by David Kerr, Edited by Lewis Rowett, Edited by Annie Young
    Physical properties
    Format: Paperback
    Number of pages: 336
    Width: 156 mm
    Height: 230 mm
    Thickness: 20 mm
    Weight: 522 g
    Language
    English
    ISBN
    ISBN 13: 9780198566311
    ISBN 10: 019856631X
    Classifications

    BIC E4L: HEA
    Nielsen BookScan Product Class 3: S6.2
    Ingram Subject Code: PI
    Libri: I-PI
    BIC subject category V2: MMG
    Warengruppen-Systematik des deutschen Buchhandels: 26990
    BIC subject category V2: MJCL2
    BISAC V2.8: MED062000
    LC subject heading:
    DC22: 616.994061
    LC subject heading: , , , , ,
    Thema V1.0: MKG, MJCL2
    Edition
    1
    Edition statement
    New ed.
    Illustrations note
    Numerous tables and line drawings
    Publisher
    Oxford University Press
    Imprint name
    Oxford University Press
    Publication date
    15 June 2006
    Publication City/Country
    Oxford
    Author Information
    Annie Young was a biochemist prior to training as a nurse. She was instrumental in starting up a home chemotherapy and gene therapy service in Birmingham, and she is now a Nurse Director covering three counties.
    Review quote
    The editors of this new book...provide a good introductory guide to a whole range of biological interventions. The authors do make the very important point that 'individualised' treatment is going to be the order of the day. All cancer are different, we have to find out how different they are with ever-improving laboratory testing, and we have to tailor treatment to suit each cancer's unique profile and bring them back under control biologically. Oncology News, Vol 1 Issue 5, This introductory guide is essential reading as the transition from the laboratory phase to clinical practice is made. Opening chapters on the cell biology of caner and the immune system set the scene, before the clinical development of biological therapies is addressed. The reader is then guided through the various methods and types of biological therapy...The potential of genetic information to benefit patients concludes this guide. [It is] edited by a team with perspectives in pharmacology, oncology and nursing, and [has] contributions from experts in the various areas of biotherapy.
    Table of contents
    Introduction ; 1. An introduction to the cell biology of cancer ; 2. An introduction to the immune system and cancer ; 3. The clinical development of biologic therapies ; 4. Kinase inhibitors ; 5. The RAS pathway - a target for anticancer therapy ; 6. The development of cell cycle active agents for cancer therapy ; 7. Therapeutic monoclonal antibodies ; 8. Antibody Directed Enzyme Prodrug Therapy (ADEPT) ; 9. Cytokines ; 10. Inhibitors of invasion and angiogenesis ; 11. Proteins, peptides and DNA vaccines for cancer ; 12. Cell based immunotherapy ; 13. Gene therapy for cancer - approaches and ethical considerations ; 14. Individualising cancer therapy ; Glossary