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    Autologous and Cancer Stem Cell Gene Therapy (Progress in Gene Therapy) (Hardback) Edited by Roger Bertolotti, Edited by Keiya Ozawa

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    DescriptionAdult or postnatal stem cells offer life-long cell replacement in tissues and organs, and are thus unavoidable targets of long-term and transient regenerative/epigenetic gene therapy for both inherited and acquired diseases; and effective anticancer therapy. In particular, autologous stem cells have been instrumental to the success of gene therapy, enabling breakthrough endonuclease-boosted gene targeting for gene correction (inherited diseases) or targeted integration of therapeutic transgenes (other disorders).This timely book highlights the pioneering translation of adult pluripotent stem cells as a substitute for tissue-specific stem cells, thereby pinpointing the invaluable potential for stem cell gene therapy applications of autologous cells to contribute to all three germ players. Pathologies are discussed in terms of stem cell repopulation dynamics, with appropriate niches (long-term engraftment) and tissues (cell turnover). Focus is also placed on the increasing number of identified tissue-specific cancer stem cells as the ultimate targets for recurrence-free cancer recovery, and on the development of armed stem cells as tumor-homing vectors for targeted anticancer stem cell gene therapy.


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  • Full bibliographic data for Autologous and Cancer Stem Cell Gene Therapy

    Title
    Autologous and Cancer Stem Cell Gene Therapy
    Authors and contributors
    Edited by Roger Bertolotti, Edited by Keiya Ozawa
    Physical properties
    Format: Hardback
    Number of pages: 488
    Width: 168 mm
    Height: 250 mm
    Thickness: 26 mm
    Weight: 1,039 g
    Language
    English
    ISBN
    ISBN 13: 9789812775863
    ISBN 10: 9812775862
    Classifications

    BIC E4L: HEA
    B&T Book Type: NF
    Nielsen BookScan Product Class 3: S6.2
    B&T Merchandise Category: TXT
    BIC subject category V2: MJCL
    Ingram Subject Code: PS
    Libri: I-PS
    B&T Modifier: Text Format: 02
    B&T General Subject: 510
    DC22: 616.99406
    Warengruppen-Systematik des deutschen Buchhandels: 16730
    B&T Modifier: Academic Level: 02
    BISAC V2.8: MED003000
    B&T Modifier: Subject Development: 59
    BISAC V2.8: PSY028000, MED062000, MED009000
    B&T Modifier: Region of Publication: 07
    LC subject heading:
    BIC subject category V2: MJZ
    DC22: 615.895
    LC subject heading: ,
    DC22: 615.8/95
    LC classification: QH588.S83 A98 2008
    Thema V1.0: MJCL, MKZV
    Publisher
    World Scientific Publishing Co Pte Ltd
    Imprint name
    World Scientific Publishing Co Pte Ltd
    Publication date
    01 March 2008
    Publication City/Country
    Singapore
    Table of contents
    Long-term Stem Cell Gene Therapy: From Current Clinical Random-Integration Achievements to Stem Cell Gene Targeting/Cybridization: From Pioneering Clinical Retroviral Gene Therapy to Experimental Site-Specific Integrative Gene Therapy; Experimental Gene Targeting with Viral Vectors; Stem Cell Gene Targeting/Cybridization: Toward Endonuclease-Boosted Gene Repair/Alteration, Custom Site-Specific Integrative Gene Therapy and Transmitochondrial Therapy/Rejuvenation; Adult Pluripotent Stem Cells: Emerging Stem Cell/Gene Therapy Breakthrough; Cancer Stem Cell Gene Therapy: Cancer Stem Cells as Breakthrough Targets of Cancer Gene Therapy; Armed Stem Cells as Tumor-Homing Vectors for Cancer Gene Therapy.