Adipose Tissue in Health and Disease

Adipose Tissue in Health and Disease


Edited by Todd A. Leff, Edited by James G. Granneman

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  • Publisher: Wiley-VCH Verlag GmbH
  • Format: Hardback | 530 pages
  • Dimensions: 174mm x 244mm x 30mm | 1,120g
  • Publication date: 10 May 2010
  • Publication City/Country: Weinheim
  • ISBN 10: 3527318577
  • ISBN 13: 9783527318575
  • Illustrations note: 500 schwarz-weiße und 20 farbige Abbildungen

Product description

This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

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Author information

Todd Leff is Associate Professor in the Department of Pathology at the Wayne State University School of Medicine in Detroit, Michigan. In 1991 he moved to the Parke-Davis Company where he became the Director of the Transcription Research Group in the Department of Cell biology. In 2002 he joined the faculty at the Wayne State. He serves on the editorial boards of the Journal of Biological Chemistry, the Journal of Lipid Research and the American Journal of Physiology. James Granneman is Professor of Psychiatry and Behavioral Neurosciences, and Pathology at Wayne State University School of Medicine. Dr. Granneman's research interests include lipolysis and adrenergic signal transduction in adipose tissues, and he serves on the editorial board of American Journal of Physiology.

Table of contents

ADIPOSE TISSUE DEVELOPMENT AND MORPHOLOGY Transcriptional Control of Adipogenesis and Fat Cell Gene Expression Development of Adipose Tissue The Cellular and Molecular Basis of Functional Differences Among Fat Depots Plasticity of The Adipose Organ Biology of Adipose Tissue Stem Cells METABOLIC FUCTIONS OF ADIPOSE TISSUE Molecular Mechanisms of Adipocyte Lipolysis New Developments in the Lipolytic Processing of Triglyceride-rich Lipoproteins Intracellular Fatty Acid Transport, Activation And Trafficking Aquaporins and Adipose Tissue Signaling Pathways Controlling Lipolysis ENDOCRINE FUNCTIONS OF ADIPOSE TISSUE Leptin Secretion and Action Adiponectin Pref-1 and ADSF/resistin, Two Secreted Factors from Adipose Tissue: Role in Adipogenesis and Insulin Resistance Adipose Tissue and Blood Pressure Regulation Adipokines, Inflammation, and Obesity ADIPOSE TISSUE AND DISEASE Depot Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk Viral Induction of Obesity and Adipogenesis Adipose Tissue Cachexia Obesity and Diabetes: Lipotoxicity Obesity and Cancer Overview of Acquired and Genetic Lipodystrophies Mouse Models of Lipodystrophy Caloric Restriction Thiazolidinedione action - Adipose Tissue PPARg and other Drugs Afffecting Adipose Tissue Early Life Programming of Adipogenesis and Adiposity COMPARITIVE AND EVOLUTIONARY ASPECTS OF ADIPOSE TISSUE Evolutionary Aspects of Obesity and Adipose Tissue Function